ARTÍCULOS EN REVISTAS INDEXADAS

2022

47. Bustos-Salgado, P., Andrade-Carrera, B., Domínguez-Villegas, V., Noé, V., Mallandrich, M.*, Colom, H., Calpena-Campmany, A., & Garduño-Ramírez, M. L. (2023). In Vitro Approaches to Explore the Anticancer

Potential of One Natural Flavanone and Four Derivatives Loaded in Biopolymeric Nanoparticles for Application in Topical Delivery Treatments. Pharmaceutics, 15(6), 1632. DOI:

10.3390/pharmaceutics15061632

46. Romero-Estrada, A.; Boto, A.; González-Christen, J.; Romero-Estudillo, I.; Garduño-Ramírez, M. L.; Razo-Hernández, R. S.; Marquina, S.; Maldonado-Magaña, A.; Columba-Palomares, M. C.; Sánchez-Carranza, J. N.; Alvarez, L.* Synthesis, Biological Evaluation, and Molecular Docking Study of 3-Amino and 3-Hydroxy- Seco A Derivatives of α-Amyrin and 3-Epilupeol as Inhibitors of COX-2 Activity and NF-kB Activation. J. Nat. Prod. 2022, acs.jnatprod.1c00827. DOI: 10.1021/acs.jnatprod.1c00827

2021

45. El Moussaoui, S.; Abo-Horan, I.; Halbaut, L.; Alonso, C.; Coderch, L.; Garduño-Ramírez, M. L.; Clares, B*.; Soriano, J. L.; Calpena, A. C.; Fernández-Campos, F.; Mallandrich, M. Polymeric Nanoparticles and Chitosan Gel Loading Ketorolac

Tromethamine to Alleviate Pain Associated with Condyloma Acuminata during the Pre- and Post-Ablation. Pharmaceutics 2021, 13 (11), 1784. DOI:10.3390/pharmaceutics13111784

44. Bustos-Salgado, P.; Andrade-Carrera, B.; Domínguez-Villegas, V.; Díaz-Garrido, N.; Rodríguez-Lagunas, M. J.; Badía, J.; Baldomà, L.; Mallandrich, M.; Calpena-Campmany, A.; Garduño-Ramírez, M. L.* Screening Anti-Inflammatory Effects of Flavanones Solutions. Int. J. Mol. Sci. 2021, 22 (16), 8878. DOI: 10.3390/ijms22168878

43. El Moussaoui, S.; Fernández-Campos, F.; Alonso, C.; Limón, D.; Halbaut, L.; Garduño-Ramirez, M. L.; Calpena, A. C.; Mallandrich, M.* Topical Mucoadhesive Alginate-Based Hydrogel Loading Ketorolac for Pain Management after Pharmacotherapy, Ablation, or Surgical Removal in Condyloma Acuminata. Gels 2021, 7 (1), 8 DOI: 10.3390/gels7010008

2020

42. Soriano, J. L.; Calpena, A. C.*; Rodríguez-Lagunas, M. J.; Domènech, Ò.; Bozal-de Febrer, N.; Garduño-Ramírez, M. L.; Clares, B. Endogenous Antioxidant Cocktail Loaded Hydrogel for Topical Wound Healing of Burns. Pharmaceutics 2020, 13 (1), 8 DOI: 10.3390/pharmaceutics13010008

41. Bustos-Salgado, P., Andrade-Carrera, B., Garduño-Ramírez, M. L., Alvarado, H., & Calpena-Campmany, A.* (2020). Quantification of one Prenylated Flavanone from Eysenhardtia platycarpa and four derivatives in Ex Vivo Human Skin Permeation Samples Applying a Validated HPLC Method. Biomolecules, 10(6), 889. https://doi.org/10.3390/biom10060889

2019

40. Limón, D.*; Talló Domínguez, K.; Garduño-Ramírez, M. L.; Andrade, B.; Calpena, A. C.; Pérez-García, L. Nanostructured Supramolecular Hydrogels: Towards the Topical Treatment of Psoriasis and Other Skin Diseases. Colloids Surfaces B Biointerfaces 2019, 181, 657–670 DOI: 10.1016/j.colsurfb.2019.06.018

39. Silva, A. M.*; Alvarado, H. L.; Abrego, G.; Martins-Gomes, C.; Garduño-Ramirez, M. L.; García, M. L.; Calpena, A. C.*; Souto, E. B. In Vitro Cytotoxicity of Oleanolic/Ursolic Acids-Loaded in PLGA Nanoparticles in Different Cell Lines. Pharmaceutics 2019, 11 (8), 362 DOI: 10.3390/pharmaceutics11080362

38. Espinoza, L. C.; Silva-Abreu, M.; Calpena, A. C.; Rodríguez-Lagunas, M. J.; Fábrega, M.-J.; Garduño-Ramírez, M. L.; Clares, B.* Nanoemulsion Strategy of Pioglitazone for the Treatment of Skin Inflammatory Diseases. Nanomedicine Nanotechnology, Biol. Med. 2019, 19, 115–125. DOI: 10.1016/j.nano.2019.03.017

2018

37. Rincón, M.; Calpena, A.*; Fabrega, M.-J.; Garduño-Ramírez, M.; Espina, M.; Rodríguez-Lagunas, M.; García, M.; Abrego, G. Development of Pranoprofen Loaded Nanostructured Lipid Carriers to Improve Its Release and Therapeutic Efficacy in Skin Inflammatory Disorders. Nanomaterials 2018, 8 (12), 1022 DOI: 10.3390/nano8121022

36. Rincón, M.; Calpena, A. C.; Clares, B.*; Espina, M.; Garduño-Ramírez, M. L.; Rodríguez-Lagunas, M. J.; García, M. L.; Abrego, G. Skin-Controlled Release Lipid Nanosystems of Pranoprofen for the Treatment of Local Inflammation and Pain. Nanomedicine 2018, nnm-2018-0195. DOI: 10.2217/nnm-2018-0195

35. Alvarado, H. L.; Calpena, A. C.; Garduno-Ramirez, M. L.; Ortiz, R.; Melguizo, C.; Prados, J. M.; Clares, B.* Nanoemulsion Strategy for Ursolic and Oleanic Acids Isolates from Plumeria Obtusa Improves Antioxidant and Cytotoxic Activity in Melanoma Cells. Anticancer. Agents Med. Chem. 2018, 18. DOI: 10.2174/1871520618666180111151846

2017

34. Andrade-Carrera, B.; Clares, B.; Noé, V.; Mallandrich, M.; Calpena, A.; García, M.; Garduño-Ramírez, M.* Cytotoxic Evaluation of (2S)-5,7-Dihydroxy-6-Prenylflavanone Derivatives Loaded PLGA Nanoparticles against MiaPaCa-2 Cells. Molecules 2017, 22 (9), 1553. DOI: 10.3390/molecules22091553

33. Mallandrich, M.; Fernández-Campos, F.; Clares, B.*; Halbaut, L.; Alonso, C.; Coderch, L.; Garduño-Ramírez, M. L.; Andrade, B.; del Pozo, A.; Lane, M. E.; Calpena, A. C. Developing Transdermal Applications of Ketorolac Tromethamine Entrapped in Stimuli Sensitive Block Copolymer Hydrogels. Pharm. Res. 2017, 34 (8), 1728–1740. DOI: 10.1007/s11095-017-2181-8

2016

32. Gómez-Calvario, V.; Garduño-Ramírez, M. L.; León-Rivera, I.; Rios, M. Y.* 1 H and 13 C NMR Data on Natural and Synthetic Capsaicinoids. Magn. Reson. Chem. 2016, 54 (4), 268–290. DOI: 10.1002/mrc.4382

31. Romero-Estrada, A.; Maldonado-Magaña, A.; González-Christen, J.; Bahena, S. M.; Garduño-Ramírez, M. L.; Rodríguez-López, V.; Alvarez, L.* Anti-Inflammatory and Antioxidative Effects of Six Pentacyclic Triterpenes Isolated from the Mexican Copal Resin of Bursera Copallifera. BMC Complement. Altern. Med. 2016, 16 (1), 422. DOI: 10.1186/s12906-016-1397-1

30. Parra, A.; Clares, B.*; Rosselló, A.; Garduño-Ramírez, M. L.; Abrego, G.; García, M. L.; Calpena, A. C. Ex Vivo Permeation of Carprofen from Nanoparticles: A Comprehensive Study through Human, Porcine and Bovine Skin as Anti-Inflammatory Agent. Int. J. Pharm. 2016, 501 (1), 10–17. DOI: 10.1016/j.ijpharm.2016.01.056

29. Abrego, G.; Alvarado, H.; Souto, E. B.*; Guevara, B.; Bellowa, L. H.; Garduño, M. L.; Garcia, M. L.; Calpena, A. C.* Biopharmaceutical Profile of Hydrogels Containing Pranoprofen-Loaded PLGA Nanoparticles for Skin Administration: In Vitro, Ex Vivo and in Vivo Characterization. Int. J. Pharm. 2016, 501 (1), 350–361. DOI: 10.1016/j.ijpharm.2016.01.071

2015

28. Alvarado, H. L.; Abrego, G.; Garduño-Ramirez, M. L.; Clares, B.*; Calpena, A. C.; García, M. L. Design and Optimization of Oleanolic/ursolic Acid-Loaded Nanoplatforms for Ocular Anti-Inflammatory Applications. Nanomedicine Nanotechnology, Biol. Med. 2015, 11 (3), 521–530. DOI: 10.1016/j.nano.2015.01.004

27. Alvarado, H. L.; Abrego, G.; Souto, E. B.*; Garduño-Ramirez, M. L.; Clares, B.; García, M. L.; Calpena, A. C.* Nanoemulsions for Dermal Controlled Release of Oleanolic and Ursolic Acids: In Vitro, Ex Vivo and in Vivo Characterization. Colloids Surfaces B Biointerfaces 2015, 130, 40–47. DOI: 10.1016/j.colsurfb.2015.03.062

26. Alvarado, H. L.; Abrego, G.; Garduño-Ramirez, M. L.; Clares, B.*; García, M. L.; Calpena, A. C. Development and Validation of a High-Performance Liquid Chromatography Method for the Quantification of Ursolic/oleanic Acids Mixture Isolated from Plumeria Obtusa. J. Chromatogr. B 2015, 983, 111–116. DOI: 10.1016/j.jchromb.2015.01.009

25. Limón, D.; Amirthalingam, E.; Rodrigues, M.; Halbaut, L.; Andrade, B.; Garduño-Ramírez, M. L.; Amabilino, D. B.; Pérez-García, L.; Calpena, A. C.* Novel Nanostructured Supramolecular Hydrogels for the Topical Delivery of Anionic Drugs. Eur. J. Pharm. Biopharm. 2015, 96, 421–436. DOI: 10.1016/j.ejpb.2015.09.007

2014

24. Salinas, R.; Arellano-García, J.; Perea-Arango, I.; Álvarez, L.; Garduño-Ramírez, M. L.; Marquina, S.; Zamilpa, A.; Castillo-España, P.* Production of the Anti-Inflammatory Compound 6-O-Palmitoyl-3-O-β-D-Glucopyranosylcampesterol by Callus Cultures of Lopezia Racemosa Cav.(Onagraceae). Molecules 2014, 19 (6), 8679–8690. DOI: 10.3390/molecules19068679

23. Rodrigues, M.; Calpena, A. C.; Amabilino, D. B.; Garduño-Ramírez, M. L.; Pérez-García, L.* Supramolecular Gels Based on a Gemini Imidazolium Amphiphile as Molecular Material for Drug Delivery. J. Mater. Chem. B 2014, 2 (33), 5419–5429. DOI: 10.1039/C4TB00450G

22. Domínguez-Villegas, V.; Clares-Naveros, B.*; García-López, M. L.; Calpena-Campmany, A. C.; Bustos-Zagal, P.; Garduño-Ramírez, M. L. Development and Characterization of Two Nano-Structured Systems for Topical Application of Flavanones Isolated from Eysenhardtia Platycarpa. Colloids Surfaces B Biointerfaces 2014, 116, 183–192. DOI: 10.1016/j.colsurfb.2013.12.009

21. Gutiérrez, D. M. A.*; Bah, M.; Garduño, M. L. R.; Mendoza, S. O. M.; Serrano, V. C. Anti-Inflammatory and Antioxidant Activities of Methanol Extracts and Alkaloid Fractions of Four Mexican Medicinal Plants of Solanaceae. African J. Tradit. Complement. Altern. Med. 2014, 11 (3), 259–267. Online

2013

20. Sierra, A. F.; Ramírez, M. L. G.; Campmany, A. C. C.; Martínez, A. R.; Naveros*, B. C. In Vivo and in Vitro Evaluation of the Use of a Newly Developed Melatonin Loaded Emulsion Combined with UV Filters as a Protective Agent against Skin Irradiation. J. Dermatol. Sci. 2013, 69 (3), 202–214. DOI: 10.1016/j.jdermsci.2012.10.013

19. Vega, E.*; Egea, M. A.; Garduño-Ramírez, M. L.; García, M. L.; Sánchez, E.; Espina, M.; Calpena, A. C. Flurbiprofen PLGA-PEG Nanospheres: Role of Hydroxy-β-Cyclodextrin on Ex Vivo Human Skin Permeation and in Vivo Topical Anti-Inflammatory Efficacy. Colloids Surfaces B Biointerfaces 2013, 110, 339–346. DOI: 10.1016/j.colsurfb.2013.04.045

18. Domínguez-Villegas, V.; García, M. L.; Calpena, A.; Clares-Naveros, B.; Garduño-Ramirez, M. L. Anti-Inflammatory, Antioxidant and Cytotoxicity Activities of Methanolic Extract and Prenylated Flavanones Isolated from Leaves of Eysehardtia Platycarpa. Nat. Prod. Commun. 2013, 8 (2), 177–180. Online 

2012

17. del Pilar Nicasio-Torres, M.*; Meckes-Fischer, M.; Aguilar-Santamaría, L.; Garduño-Ramírez, M. L.; Chávez-Ávila, V. M.; Cruz-Sosa, F. Production of Chlorogenic Acid and Isoorientin Hypoglycemic Compounds in Cecropia Obtusifolia Calli and in Cell Suspension Cultures with Nitrate Deficiency. Acta Physiol. Plant. 2012, 34 (1), 307–316. DOI: 10.1007/s11738-011-0830-9

16. Garduno-Ramirez, M. L.; Clares, B.; Dominguez-Villegas, V.; Peraire, C.; Ruiz, M. A.; Garcia, M. L.; Calpena, A. C. Skin Permeation of Cacalol, Cacalone and 6-Epi-Cacalone Sesquiterpenes from a Nanoemulsion. Nat. Prod. Commun. 2012, 7 (7), 821–823. Online 

2010

15. Domínguez, F.*; Chávez, M.; Garduno-Ramirez, M. L.; Chávez-Avila, V. M.; Mata, M.; Cruz-Sosa, F. Honokiol and Magnolol Production by in Vitro Micropropagated Plants of Magnolia Dealbata, an Endangered Endemic Mexican Species. Nat. Prod. Commun. 2010, 5 (2), 235–240. Online 

14. Clarés Naveros, B.*; Martín Villena, M. J.; Ruiz Martínez, M. A.; Garduño Ramírez, M. L.; Gallardo Lara, V.; Calpena Campmany, A. C. Valoración de Una Experiencia de Innovación Docente En La Asignatura Tecnología Farmacéutica Especial de La Facultad de Farmacia de La Universidad de Granada. 2010. DOI: 10481/27261

13. Fernández Campos, F.*; Viladrosa, L.; Clarés Naveros, B.; Garduño Ramírez, M. L.; Calpena Campmany, A. C. Virtualización de Las Prácticas de Biofarmacia: Ensayos de Disolución de Diferentes Formas de Dosificación. 2010. DOI: 10481/27331

2009

12. Domínguez, F.; Chávez, M.; Garduño-Ramírez, M. L.; Chávez-Ávila, V. M.; Mata, M.; Cruz-Sosa, F. Cultures of Magnolia Dealbata Zucc. 2009, 939-943. Online 

2008

11. Acevedo-Quiroz, N.; Dominguez-Villegas, V.; Garduno-Ramirez, M. L. Structure-Activity Relationships of Modified Eremophilanes and Anti-Inflammatory Activity Using the TPA Mouse Edema Ear Test. Nat. Prod. Commun. 2008, 3 (3), 313–317.

2007

10. Qadeer, G.; Rama, N. H.*; Garduño-Ramírez, M. L. Synthesis and Anti-Inflammatory Activity of Fluorinated Isocoumarins and 3, 4-Dihydroisocoumarins. J. Fluor. Chem. 2007, 128 (6), 641–646. DOI: 10.1016/j.jfluchem.2007.02.021

2006

9. Narváez-Mastache, J. M.; Garduño-Ramírez, M. L.; Alvarez, L.; Delgado, G.* Antihyperglycemic Activity and Chemical Constituents of Eysenhardtia Platycarpa. J. Nat. Prod. 2006, 69 (12), 1687–1691. DOI: 10.1021/np060166z

8. Osuna, L.*; Tapia-Pérez, M. E.; Figueroa, O.; Jiménez-Ferrer, E.; Garduño-Ramírez, M. L.; González-Garza, M. T.; Carranza-Rosales, P.; Cruz-Vega, D. E.* Micropropagation of Lepidium Virginicum (Brassicaceae), a Plant with Antiprotozoal Activity. Vitr. Cell. Dev. Biol. 2006, 42 (6), 596–600. DOI: 10.1079/IVP2006826

7. Activity, A. Chemical Constituents of Eysenhardtia Platycarpa Narvaez-Mastache, Jose M.; Garduno-Ramirez, Maria Luisa; Alvarez, Laura; Delgado. G.* Nat. Prod. 2006, 69 (12), 1687–1691. DOI: 10.1021/np060166z

2005

6. Herrera-Salgado, Y.; Garduño-Ramírez, M. L.; Vázquez, L.; Rios, M. Y.; Alvarez, L.* Myo-Inositol-Derived Glycolipids with Anti-Inflammatory Activity from Solanum L Anceolatum. J. Nat. Prod. 2005, 68 (7), 1031–1036. DOI: 10.1021/np050054s

5. Ortiz-Andrade, R. R.; Rodríguez-López, V.; Garduño-Ramírez, M. L.; Castillo-España, P.; Estrada-Soto, S.* Anti-Diabetic Effect on Alloxanized and Normoglycemic Rats and Some Pharmacological Evaluations of Tournefortia Hartwegiana. J. Ethnopharmacol. 2005, 101 (1), 37–42. DOI: 10.1016/j.jep.2005.03.022

2003

4. Garduño-Ramírez, M. L.; Delgado, G. New Eremophilanoids from the Roots of Psacalium Radulifolium. Hypoglycemic, Antihyperglycemic and Anti-Oxidant Evaluations. J. Mex. Chem. Soc 2003, 47 (2), 160–166. Online

2001

3. Marquina, S.; Maldonado, N.; Garduño-Ramı́rez, M. L.; Aranda, E.; Villarreal, M. L.; Navarro, V.; Bye, R.; Delgado, G.; Alvarez, L.* Bioactive Oleanolic Acid Saponins and Other Constituents from the Roots of Viguiera Decurrens. Phytochemistry 2001, 56 (1), 93–97. DOI: 10.1016/S0031-9422(00)00283-1

2. Ortega, A.*; Garcı́a, P. E.; Cárdenas, J.; Mancera, C.; Marquina, S.; del Carmen Garduño, M. L.; Maldonado, E. Methyl Dodonates, a New Type of Diterpenes with a Modified Clerodane Skeleton from Dodonaea Viscosa. Tetrahedron 2001, 57 (15), 2981–2989. DOI: 10.1016/S0040-4020(01)00161-2

1. Garduño-Ramírez, M. L.; Trejo, A.; Navarro, V.; Bye, R.; Linares, E.; Delgado, G.* New Modified Eremophilanes from the Roots of Psacalium R Adulifolium. J. Nat. Prod. 2001, 64 (4), 432–435. DOI: 10.1021/np000385z

• Desarrollo y validación de un método analítico por HLPC para cuantificación de Metil dodonato A.
• Estudio del potencial antioxidante de fracciones y compuestos polares naturales y acetilados del extracto de las hojas Eysenhardtia platycarpa. 
• Aplicación del concepto de calidad basada en el diseño (QbD) en el desarrollo y optimización de formulaciones nanoestructuradas de la mezcla natural de ácido ursólico y ácido oleanólico con actividad antiinflamatoria por vía tópica.

1. Córdova Ocampo Daniela
2. Mejia Garcia Jose Alberto
3. Díaz Peralta Lizet 
4. Quintana Padilla Isaura
5. Paola Bustos Salgado
6. Valeri Domínguez Villegas
7. Betsy Valente Velázquez 
8. Hernández Rodríguez Christopher
9. Valladares Michelle
10. López León Abril 
11. Salazar Ortigoza Lorena Ariana
12. Carvajal Peralta Danae
13. Martínez Jápera Kitzia Paola
14. Castañeda Recilla Diego
15. Neveros Alaniz Andrea
16. Rojas Guadarrama Evelyn
17. León Astudillo Adilene Magdalia
18. Berenice Andrade Carrera
19. Barrera Manjarrez Aura Regina
20. Alicia Evelyne Ramírez Hernández
21. Cecilia Lara Rivas
22. Yesica Vanessa de la Cruz Contreras
23. Dayra Martínez Díaz