PH- Morales Rojas Hugo
Hugo Morales Rojas

Doctorado en Química, Rutgers University, EUA (2001)
Profesor- Titular B
SNI: Nivel II
Líneas de Investigación: Química Supramolecular, Físicoquímica
Cuerpo Académico: Química Inorgánica y Supramolecular
hugom@uaem.mx | Teléfono: +52 777 329 79 97 Ext.6032
ORCID: 0000-0002-9194-6904 | Scopus Author ID: 6603488114 | 
2018

28. Córdova-Villanueva, E. N.; Rodríguez-Ruiz, C.; Sánchez-Guadarrama, O.; Rivera-Islas, J.; Herrera-Ruiz, D.; Morales-Rojas, H.; Höpfl, H.* Diastereomeric Salt Formation by the γ-Amino Acid RS-Baclofen and L-Malic Acid - Stabilization by Strong Heterosynthons Based on Hydrogen Bonds between RNH3+ and COOH/COO- Groups. Cryst. Growth Des. 2018, acs.cgd.8b00990. DOI: 10.1021/acs.cgd.8b00990

27. Campillo-Alvarado, G.; Vargas-Olvera, E. C.; Höpfl, H.*; Herrera-España, A. D.; Sánchez-Guadarrama, O.; Morales-Rojas, H.*; MacGillivray, L. R.; Rodríguez-Molina, B.; Farfán, N. Self-Assembly of Fluorinated Boronic Esters and 4,4′-Bipyridine into 2:1 N→B Adducts and Inclusion of Aromatic Guest Molecules in the Solid State: Application for the Separation of O, M, P -Xylene. Cryst. Growth Des. 2018, acs.cgd.7b01368. DOI: 10.1021/acs.cgd.7b01368

2017

26. Arenas-García, J. I.; Herrera-Ruiz, D.*; Morales-Rojas, H.; Höpfl, H.* Interrelation of the Dissolution Behavior and Solid-State Features of Acetazolamide Cocrystals. Eur. J. Pharm. Sci. 2017, 96, 299–308. DOI: 10.1016/j.ejps.2016.09.025

2016

25. Sánchez-Guadarrama, O.; Mendoza-Navarro, F.; Cedillo-Cruz, A.; Jung-Cook, H.; Arenas-García, J. I.; Delgado-Díaz, A.; Herrera-Ruiz, D.*; Morales-Rojas, H.; Höpfl, H.* Chiral Resolution of RS -Praziquantel via Diastereomeric Co-Crystal Pair Formation with <span Style=“font-Variant:small-Caps;”>l</span> -Malic Acid. Crystal Growth & Design 2016, 16 (1), 307–314. DOI: 10.1021/acs.cgd.5b01254

2015

24. Herrera-España, A. D.; Campillo-Alvarado, G.; Román-Bravo, P.; Herrera-Ruiz, D.; Höpfl, H.; Morales-Rojas, H.* Selective Isolation of Polycyclic Aromatic Hydrocarbons by Self-Assembly of a Tunable N→ B Clathrate. Cryst. Growth Des. 2015, 15 (4), 1572–1576. DOI: 10.1021/acs.cgd.5b00219

23. Hernández-Paredes, J.; Olvera-Tapia, A. L.; Arenas-García, J. I.; Höpfl, H.*; Morales-Rojas, H.; Herrera-Ruiz, D.; Gonzaga-Morales, A. I.; Rodríguez-Fragoso, L. On Molecular Complexes Derived from Amino Acids and Nicotinamides in Combination with Boronic Acids. CrystEngComm 2015, 17 (28), 5166–5186. DOI: 10.1039/C4CE01934B

2014

22. Martínez-Alejo, J. M.; Domínguez-Chávez, J. G.; Rivera-Islas, J.; Herrera-Ruiz, D.*; Höpfl, H.; Morales-Rojas, H.*; Senosiain, J. P. A Twist in Cocrystals of Salts: Changes in Packing and Chloride Coordination Lead to Opposite Trends in the Biopharmaceutical Performance of Fluoroquinolone Hydrochloride Cocrystals. Cryst. Growth Des. 2014, 14 (6), 3078–3095. DOI: 10.1021/cg500345a

21. Cabrera-Rivera, F. A.; Escalante, J.*; Morales-Rojas, H.; Zigler, D. F.; Schmidt, R. D.; Jarocha, L. E.; Forbes, M. D. E.* Photophysical Properties of 2, 3-Dihydroquinazolin-4 (1H)-One Derivatives. J. Photochem. Photobiol. A Chem. 2014, 294, 31–37. DOI: 10.1016/j.jphotochem.2014.07.005

20. Félix-Sonda, B. C.; Rivera-Islas, J.; Herrera-Ruiz, D.*; Morales-Rojas, H.; Höpfl, H.* Nitazoxanide Cocrystals in Combination with Succinic, Glutaric, and 2, 5-Dihydroxybenzoic Acid. Cryst. Growth Des. 2014, 14 (3), 1086–1102. DOI: 10.1021/cg4015916

2013

19. Espinosa-Lara, J. C.; Guzman-Villanueva, D.; Arenas-García, J. I.; Herrera-Ruiz, D.*; Rivera-Islas, J.; Román-Bravo, P.; Morales-Rojas, H.; Höpfl, H.* Cocrystals of Active Pharmaceutical Ingredients—Praziquantel in Combination with Oxalic, Malonic, Succinic, Maleic, Fumaric, Glutaric, Adipic, And Pimelic Acids. Crystal Growth & Design 2013, 13 (1), 169–185. DOI: 10.1021/cg301314w

18. Rodriguez-Fragoso L., Martínez de los Ríos, A., Osuna-Martínez, U., Morales-Rojas, H., y Reyes-Esparza, J.* A Thymic Metallo-Peptide Influences Lymphocyte, Monocyte and Thymocyte Responses. Journal of Physical Chemistry & Biophysics 2013, 3 (3). DOI: 10.4172/2161-0398.1000119

2012

17. Arenas-García, J. I.; Herrera-Ruiz, D.*; Mondragón-Vásquez, K.; Morales-Rojas, H.; Höpfl, H.* Modification of the Supramolecular Hydrogen-Bonding Patterns of Acetazolamide in the Presence of Different Cocrystal Formers: 3:1, 2:1, 1:1, and 1:2 Cocrystals from Screening with the Structural Isomers of Hydroxybenzoic Acids, Aminobenzoic Acids, Hydroxybenzamides, Aminobenzamides, Nicotinic Acids, Nicotinamides, and 2,3-Dihydroxybenzoic Acids. Crystal Growth & Design 2012, 12 (2), 811–824. DOI: 10.1021/cg201140g

2010

16. Arenas-García, J. I.; Herrera-Ruiz, D.*; Mondragón-Vásquez, K.; Morales-Rojas, H.; Höpfl, H.* Co-Crystals of Active Pharmaceutical Ingredients - Acetazolamide. Crystal Growth & Design 2010, 10 (8), 3732–3742. DOI: 10.1021/cg1005693

2009

15. Arroyo, M.*; Mendoza, C.; Bernès, S.; Torrens, H.; Morales-Rojas, H. Five-Coordinate Pentafluorobenzothiolate osmium(IV) Complexes [Os(SC6F5)4(P(C6H4X-4)3)] (X=OCH3, CH3, F, Cl or CF3): Solid and Solution Structural Characterization. Polyhedron 2009, 28 (13), 2625–2634. DOI: 10.1016/j.poly.2009.05.044

14. Fuentes-Martínez, J. P.; Toledo-Martínez, I.; Román-Bravo, P.; García, P. G. y; Godoy-Alcántar, C.*; López-Cardoso, M.; Morales-Rojas, H.* Diorganotin(IV) Dithiocarbamate Complexes as Chromogenic Sensors of Anion Binding. Polyhedron 2009, 28 (18), 3953–3966. DOI: 10.1016/j.poly.2009.09.010

13. Mondragón-Vásquez, K.; Morales-Rojas, H.* Molecular Recognition of Cationic Phenothiazinium and Phenoxazinium Dyes with π-Extended 2′-Deoxyadenosine Nucleotides. Chemical Communications 2009, No. 44, 6726. DOI: 10.1039/b913315a

2008

12. Cruz-Huerta, J.; Carillo-Morales, M.; Santacruz-Juárez, E.; Hernández-Ahuactzi, I. F.; Escalante-García, J.; Godoy-Alcantar, C.; Guerrero-Alvarez, J. A.; Höpfl, H.*; Morales-Rojas, H.; Sánchez, M. Macrocyclic Diorganotin Complexes of γ-Amino Acid Dithiocarbamates as Hosts for Ion-Pair Recognition. Inorganic Chemistry 2008, 47 (21), 9874–9885. DOI: 10.1021/ic8007987

11. Santacruz-Juárez, E.; Cruz-Huerta, J.; Hernández-Ahuactzi, I. F.; Reyes-Martínez, R.; Tlahuext, H.; Morales-Rojas, H.; Höpfl, H.* 24- and 26-Membered Macrocyclic Diorganotin(IV) Bis-Dithiocarbamate Complexes with N , N′ -Disubstituted 1,3- and 1,4-Bis(aminomethyl)benzene and 1,1′-Bis(aminomethyl)ferrocene as Spacer Groups. Inorganic Chemistry 2008, 47 (21), 9804–9812. DOI: 10.1021/ic801464s

2004

10. Moss, R. A.*; Morales-Rojas, H.; Vijayaraghavan, S.; Tian, J. Metal-Cation-Mediated Hydrolysis of Phosphonoformate Diesters: Chemoselectivity and Catalysis 1. Journal of the American Chemical Society 2004, 126 (35), 10923–10936. DOI: 10.1021/ja030437h

2002

9. Flores‐Villalobos, A.; Morales‐Rojas, H.; Escalante‐Tovar, S.; Yatsimirsky, A. K.* Recognition of Protonated Aliphatic Α, Ω‐diamines by Coproporphyrin I Tetraanion in Water. J. Phys. Org. Chem. 2002, 15 (2), 83–93. DOI: 10.1002/poc.454

8. Morales-Rojas, H.; Kool, E. T.* A Porphyrin C -Nucleoside Incorporated into DNA. Organic Letters 2002, 4 (25), 4377–4380. DOI: 10.1021/ol0267376

7. Morales-Rojas, H.; Moss, R. A.* Phosphorolytic Reactivity of O -Iodosylcarboxylates and Related Nucleophiles. Chemical Reviews 2002, 102 (7), 2497–2522. DOI: 10.1021/cr9405462

6. Moss, R. A.*; Gong, P. K.; Morales-Rojas, H. Stereochemical Study of Phosphonothioate Cleavage by a Metallomicelle. Organic Letters 2002, 4 (11), 1835–1838. DOI: 10.1021/ol0200394

2001

5. Moss, R. A.*; Morales-Rojas, H. Chemoselectivity in Metal Cation Mediated Hydrolysis of a Phosphonoformate Diester. Journal of the American Chemical Society 2001, 123 (30), 7457–7458. DOI: 10.1021/ja004156a

2000

4. Moss, R. A.*; Morales-Rojas, H. Kinetics of Cleavage of Thiophosphates and Phosphonothioates by Micellar Iodosocarboxylates and Copper Metallomicelles. Langmuir 2000, 16 (16), 6485–6491. DOI: 10.1021/la000462q

1999

3. Morales‐Rojas, H.; Yatsimirsky, A. K.* Medium Effects on the Dimerization of coproporphyrin‐I Free Base. J. Phys. Org. Chem. 1999, 12 (5), 377–387. DOI: 10.1002/(SICI)1099-1395(199905)12:5<377::AID-POC137>3.0.CO;2-0

2. Moss, R. A.*; Morales-Rojas, H.; Zhang, H.; Park, B.-D. Cleavage of VX Simulants by Micellar Iodoso- and Iodoxybenzoate. Langmuir 1999, 15 (8), 2738–2744. DOI: 10.1021/la9816151

Moss, R. A.*; Morales-Rojas, H. Loci of Ceric Cation Mediated Hydrolyses of Dimethyl Phosphate and Methyl Methylphosphonate. Organic Letters 1999, 1 (11), 1791–1793. DOI: 10.1021/ol990285o

      
Publicaciones en libros (capítulos)

H. Morales-Rojas, D. Herrera-Ruiz, and G.T. Knipp. Chapter 3 Thermodynamics in Martin's Physical Pharmacy: Physical Chemical Principles in the Pharmaceutical Sciences. Fifth Edition. Editor Patrick J. Sinko, Lippincott Williams & Wilkins, Baltimore, MD, USA. 2006 ISBN 078175027X.

G.T. Knipp, D. Herrera-Ruiz and H. Morales-Rojas. Chapter 4 Physical Properties of Drug Molecules in Martin's Physical Pharmacy: Physical Chemical Principles in the Pharmaceutical Sciences. Fifth Edition. Editor Patrick J. Sinko, Lippincott Williams & Wilkins, Baltimore, MD, USA. 2006 ISBN 078175027X.

Patentes Otorgadas

1. Morales Rojas, H., Domínguez Chávez, J.G., Herrera Ruiz, D., Höpfl, H., Senosiain Peláez, J.P., Martínez Alejo, J.M., “Nuevas Formas Sólidas de Antibióticos”. Suscritas bajo el convenio UAEM-Laboratorios Senosiain S.A. de C.V. La patentes se encuentran otorgadas en México (MX320915) el 6 de Junio del 2014 y en los Estados Unidos (US009290492B2) el 22 de Marzo del 2016. Derwent Innovation Index: 2012-P64133 [43].

Herrera Ruiz, D., Mondragón Vásquez, K., Morales Rojas H., Senosiain Peláez, J. P., Höpfl, H., “Nuevas Formas Sólidas de Inhibidores de Fosfodiesterasa Tipo 5”. Suscritas bajo el convenio UAEM-Laboratorios Senosiain S.A. de C.V. Las patentes se encuentran otorgadas en España (ES2530423) el 21 de Enero del 2016 y en los Estados Unidos (US0092789970B2) el 8 de Marzo del 2016. Derwent Innovation Index: 2014-A73324 [65].

Reyes-Esparza, J. A., Rodríguez-Fragoso, M., Badillo-Jiménez, A. L., Torres-Aguilar L., J. Osuna Martínez, L. U., Martínez de los Ríos-Corsino, A. A, Arjona-Canul, C. A., Morales-Rojas, H. “Metalopéptidos Inmonomoduladores (IMMP) y Composiciones que los Contienen”, No. MX/a/2011/010190; No. PCT/MX2011/000117. La Universidad Autónoma del Estado de Morelos es propietaria de la patente concedida en México (MX339762) el 27 de Mayo del 2016. Derwent Innovation Index: 2013-F09838 [76].

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