PH- Garduño Ramírez Maria Luisa del Carmen
María Luisa del Carmen Garduño Ramírez

Doctorado en Ciencias Químicas, Universidad Nacional Autónoma de México (2001)
Profesor: Titular A
SNI: Nivel I
Líneas de Investigación: Química de Productos Naturales
Cuerpo Académico: Productos Naturales
lgarduno@uaem.mx| Teléfono: +52 777 329 79 97 Ext.6029
ORCID: 0000-0001-5041-5587| ResearcherID: L-6510-2014| 
Scopus Author ID: 55993788100| Google Académico 
2018


37. Rincón, M.; Calpena, A.*; Fabrega, M.-J.; Garduño-Ramírez, M.; Espina, M.; Rodríguez-Lagunas, M.; García, M.; Abrego, G. Development of Pranoprofen Loaded Nanostructured Lipid Carriers to Improve Its Release and Therapeutic Efficacy in Skin Inflammatory Disorders. Nanomaterials 2018, 8 (12), 1022 DOI: 10.3390/nano8121022

36. Rincón, M.; Calpena, A. C.; Clares, B.*; Espina, M.; Garduño-Ramírez, M. L.; Rodríguez-Lagunas, M. J.; García, M. L.; Abrego, G. Skin-Controlled Release Lipid Nanosystems of Pranoprofen for the Treatment of Local Inflammation and Pain. Nanomedicine 2018, nnm-2018-0195. DOI: 10.2217/nnm-2018-0195

35. Alvarado, H. L.; Calpena, A. C.; Garduno-Ramirez, M. L.; Ortiz, R.; Melguizo, C.; Prados, J. M.; Clares, B.* Nanoemulsion Strategy for Ursolic and Oleanic Acids Isolates from Plumeria Obtusa Improves Antioxidant and Cytotoxic Activity in Melanoma Cells. Anticancer. Agents Med. Chem. 2018, 18. DOI: 10.2174/1871520618666180111151846
 
2017

34. Andrade-Carrera, B.; Clares, B.; Noé, V.; Mallandrich, M.; Calpena, A.; García, M.; Garduño-Ramírez, M.* Cytotoxic Evaluation of (2S)-5,7-Dihydroxy-6-Prenylflavanone Derivatives Loaded PLGA Nanoparticles against MiaPaCa-2 Cells. Molecules 2017, 22 (9), 1553. DOI: 10.3390/molecules22091553

33. Mallandrich, M.; Fernández-Campos, F.; Clares, B.*; Halbaut, L.; Alonso, C.; Coderch, L.; Garduño-Ramírez, M. L.; Andrade, B.; del Pozo, A.; Lane, M. E.; Calpena, A. C. Developing Transdermal Applications of Ketorolac Tromethamine Entrapped in Stimuli Sensitive Block Copolymer Hydrogels. Pharm. Res. 2017, 34 (8), 1728–1740. DOI: 10.1007/s11095-017-2181-8

2016

32. Gómez-Calvario, V.; Garduño-Ramírez, M. L.; León-Rivera, I.; Rios, M. Y.* 1 H and 13 C NMR Data on Natural and Synthetic Capsaicinoids. Magn. Reson. Chem. 2016, 54 (4), 268–290. DOI: 10.1002/mrc.4382

31. Romero-Estrada, A.; Maldonado-Magaña, A.; González-Christen, J.; Bahena, S. M.; Garduño-Ramírez, M. L.; Rodríguez-López, V.; Alvarez, L.* Anti-Inflammatory and Antioxidative Effects of Six Pentacyclic Triterpenes Isolated from the Mexican Copal Resin of Bursera Copallifera. BMC Complement. Altern. Med. 2016, 16 (1), 422. DOI: 10.1186/s12906-016-1397-1

30. Parra, A.; Clares, B.*; Rosselló, A.; Garduño-Ramírez, M. L.; Abrego, G.; García, M. L.; Calpena, A. C. Ex Vivo Permeation of Carprofen from Nanoparticles: A Comprehensive Study through Human, Porcine and Bovine Skin as Anti-Inflammatory Agent. Int. J. Pharm. 2016, 501 (1), 10–17. DOI: 10.1016/j.ijpharm.2016.01.056

29. Abrego, G.; Alvarado, H.; Souto, E. B.*; Guevara, B.; Bellowa, L. H.; Garduño, M. L.; Garcia, M. L.; Calpena, A. C.* Biopharmaceutical Profile of Hydrogels Containing Pranoprofen-Loaded PLGA Nanoparticles for Skin Administration: In Vitro, Ex Vivo and in Vivo Characterization. Int. J. Pharm. 2016, 501 (1), 350–361. DOI: 10.1016/j.ijpharm.2016.01.071

2015

28. Alvarado, H. L.; Abrego, G.; Garduño-Ramirez, M. L.; Clares, B.*; Calpena, A. C.; García, M. L. Design and Optimization of Oleanolic/ursolic Acid-Loaded Nanoplatforms for Ocular Anti-Inflammatory Applications. Nanomedicine Nanotechnology, Biol. Med. 2015, 11 (3), 521–530. DOI: 10.1016/j.nano.2015.01.004

27. Alvarado, H. L.; Abrego, G.; Souto, E. B.*; Garduño-Ramirez, M. L.; Clares, B.; García, M. L.; Calpena, A. C.* Nanoemulsions for Dermal Controlled Release of Oleanolic and Ursolic Acids: In Vitro, Ex Vivo and in Vivo Characterization. Colloids Surfaces B Biointerfaces 2015, 130, 40–47. DOI: 10.1016/j.colsurfb.2015.03.062

26. Alvarado, H. L.; Abrego, G.; Garduño-Ramirez, M. L.; Clares, B.*; García, M. L.; Calpena, A. C. Development and Validation of a High-Performance Liquid Chromatography Method for the Quantification of Ursolic/oleanic Acids Mixture Isolated from Plumeria Obtusa. J. Chromatogr. B 2015, 983, 111–116. DOI: 10.1016/j.jchromb.2015.01.009

25. Limón, D.; Amirthalingam, E.; Rodrigues, M.; Halbaut, L.; Andrade, B.; Garduño-Ramírez, M. L.; Amabilino, D. B.; Pérez-García, L.; Calpena, A. C.* Novel Nanostructured Supramolecular Hydrogels for the Topical Delivery of Anionic Drugs. Eur. J. Pharm. Biopharm. 2015, 96, 421–436. DOI: 10.1016/j.ejpb.2015.09.007

2014

24. Salinas, R.; Arellano-García, J.; Perea-Arango, I.; Álvarez, L.; Garduño-Ramírez, M. L.; Marquina, S.; Zamilpa, A.; Castillo-España, P.* Production of the Anti-Inflammatory Compound 6-O-Palmitoyl-3-O-β-D-Glucopyranosylcampesterol by Callus Cultures of Lopezia Racemosa Cav.(Onagraceae). Molecules 2014, 19 (6), 8679–8690. DOI: 10.3390/molecules19068679

23. Rodrigues, M.; Calpena, A. C.; Amabilino, D. B.; Garduño-Ramírez, M. L.; Pérez-García, L.* Supramolecular Gels Based on a Gemini Imidazolium Amphiphile as Molecular Material for Drug Delivery. J. Mater. Chem. B 2014, 2 (33), 5419–5429. DOI: 10.1039/C4TB00450G

22. Domínguez-Villegas, V.; Clares-Naveros, B.*; García-López, M. L.; Calpena-Campmany, A. C.; Bustos-Zagal, P.; Garduño-Ramírez, M. L. Development and Characterization of Two Nano-Structured Systems for Topical Application of Flavanones Isolated from Eysenhardtia Platycarpa. Colloids Surfaces B Biointerfaces 2014, 116, 183–192. DOI: 10.1016/j.colsurfb.2013.12.009

21. Gutiérrez, D. M. A.*; Bah, M.; Garduño, M. L. R.; Mendoza, S. O. M.; Serrano, V. C. Anti-Inflammatory and Antioxidant Activities of Methanol Extracts and Alkaloid Fractions of Four Mexican Medicinal Plants of Solanaceae. African J. Tradit. Complement. Altern. Med. 2014, 11 (3), 259–267. Online: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202447/

2013

20. Sierra, A. F.; Ramírez, M. L. G.; Campmany, A. C. C.; Martínez, A. R.; Naveros*, B. C. In Vivo and in Vitro Evaluation of the Use of a Newly Developed Melatonin Loaded Emulsion Combined with UV Filters as a Protective Agent against Skin Irradiation. J. Dermatol. Sci. 2013, 69 (3), 202–214. DOI: 10.1016/j.jdermsci.2012.10.013

19. Vega, E.*; Egea, M. A.; Garduño-Ramírez, M. L.; García, M. L.; Sánchez, E.; Espina, M.; Calpena, A. C. Flurbiprofen PLGA-PEG Nanospheres: Role of Hydroxy-β-Cyclodextrin on Ex Vivo Human Skin Permeation and in Vivo Topical Anti-Inflammatory Efficacy. Colloids Surfaces B Biointerfaces 2013, 110, 339–346. DOI: 10.1016/j.colsurfb.2013.04.045

18. Domínguez-Villegas, V.; García, M. L.; Calpena, A.; Clares-Naveros, B.; Garduño-Ramirez, M. L. Anti-Inflammatory, Antioxidant and Cytotoxicity Activities of Methanolic Extract and Prenylated Flavanones Isolated from Leaves of Eysehardtia Platycarpa. Nat. Prod. Commun. 2013, 8 (2), 177–180. Online http://pesquisa.bvsalud.org/ghl/resource/en/mdl-23513722

2012

17. del Pilar Nicasio-Torres, M.*; Meckes-Fischer, M.; Aguilar-Santamaría, L.; Garduño-Ramírez, M. L.; Chávez-Ávila, V. M.; Cruz-Sosa, F. Production of Chlorogenic Acid and Isoorientin Hypoglycemic Compounds in Cecropia Obtusifolia Calli and in Cell Suspension Cultures with Nitrate Deficiency. Acta Physiol. Plant. 2012, 34 (1), 307–316. DOI: 10.1007/s11738-011-0830-9

16. Garduno-Ramirez, M. L.; Clares, B.; Dominguez-Villegas, V.; Peraire, C.; Ruiz, M. A.; Garcia, M. L.; Calpena, A. C. Skin Permeation of Cacalol, Cacalone and 6-Epi-Cacalone Sesquiterpenes from a Nanoemulsion. Nat. Prod. Commun. 2012, 7 (7), 821–823. Online http://europepmc.org/abstract/med/22908555

2010

15. Domínguez, F.*; Chávez, M.; Garduno-Ramirez, M. L.; Chávez-Avila, V. M.; Mata, M.; Cruz-Sosa, F. Honokiol and Magnolol Production by in Vitro Micropropagated Plants of Magnolia Dealbata, an Endangered Endemic Mexican Species. Nat. Prod. Commun. 2010, 5 (2), 235–240. Online https://www.ncbi.nlm.nih.gov/pubmed/20334134

14. Clarés Naveros, B.*; Martín Villena, M. J.; Ruiz Martínez, M. A.; Garduño Ramírez, M. L.; Gallardo Lara, V.; Calpena Campmany, A. C. Valoración de Una Experiencia de Innovación Docente En La Asignatura Tecnología Farmacéutica Especial de La Facultad de Farmacia de La Universidad de Granada. 2010. DOI: 10481/27261

13. Fernández Campos, F.*; Viladrosa, L.; Clarés Naveros, B.; Garduño Ramírez, M. L.; Calpena Campmany, A. C. Virtualización de Las Prácticas de Biofarmacia: Ensayos de Disolución de Diferentes Formas de Dosificación. 2010. DOI: 10481/27331

2009

12. Domínguez, F.; Chávez, M.; Garduño-Ramírez, M. L.; Chávez-Ávila, V. M.; Mata, M.; Cruz-Sosa, F. Cultures of Magnolia Dealbata Zucc. 2009, 939-943. Online https://europepmc.org/abstract/med/19731598

2008

11. Acevedo-Quiroz, N.; Dominguez-Villegas, V.; Garduno-Ramirez, M. L. Structure-Activity Relationships of Modified Eremophilanes and Anti-Inflammatory Activity Using the TPA Mouse Edema Ear Test. Nat. Prod. Commun. 2008, 3 (3), 313–317.

2007

10. Qadeer, G.; Rama, N. H.*; Garduño-Ramírez, M. L. Synthesis and Anti-Inflammatory Activity of Fluorinated Isocoumarins and 3, 4-Dihydroisocoumarins. J. Fluor. Chem. 2007, 128 (6), 641–646. DOI: 10.1016/j.jfluchem.2007.02.021

2006

9. Narváez-Mastache, J. M.; Garduño-Ramírez, M. L.; Alvarez, L.; Delgado, G.* Antihyperglycemic Activity and Chemical Constituents of Eysenhardtia Platycarpa. J. Nat. Prod. 2006, 69 (12), 1687–1691. DOI: 10.1021/np060166z

8. Osuna, L.*; Tapia-Pérez, M. E.; Figueroa, O.; Jiménez-Ferrer, E.; Garduño-Ramírez, M. L.; González-Garza, M. T.; Carranza-Rosales, P.; Cruz-Vega, D. E.* Micropropagation of Lepidium Virginicum (Brassicaceae), a Plant with Antiprotozoal Activity. Vitr. Cell. Dev. Biol. 2006, 42 (6), 596–600. DOI: 10.1079/IVP2006826

7. Activity, A. Chemical Constituents of Eysenhardtia Platycarpa Narvaez-Mastache, Jose M.; Garduno-Ramirez, Maria Luisa; Alvarez, Laura; Delgado. G.* Nat. Prod. 2006, 69 (12), 1687–1691. DOI: 10.1021/np060166z

2005

6. Herrera-Salgado, Y.; Garduño-Ramírez, M. L.; Vázquez, L.; Rios, M. Y.; Alvarez, L.* Myo-Inositol-Derived Glycolipids with Anti-Inflammatory Activity from Solanum L Anceolatum. J. Nat. Prod. 2005, 68 (7), 1031–1036. DOI: 10.1021/np050054s

5. Ortiz-Andrade, R. R.; Rodríguez-López, V.; Garduño-Ramírez, M. L.; Castillo-España, P.; Estrada-Soto, S.* Anti-Diabetic Effect on Alloxanized and Normoglycemic Rats and Some Pharmacological Evaluations of Tournefortia Hartwegiana. J. Ethnopharmacol. 2005, 101 (1), 37–42. DOI: 10.1016/j.jep.2005.03.022

2003

4. Garduño-Ramírez, M. L.; Delgado, G. New Eremophilanoids from the Roots of Psacalium Radulifolium. Hypoglycemic, Antihyperglycemic and Anti-Oxidant Evaluations. J. Mex. Chem. Soc 2003, 47 (2), 160–166.

2001

3. Marquina, S.; Maldonado, N.; Garduño-Ramı́rez, M. L.; Aranda, E.; Villarreal, M. L.; Navarro, V.; Bye, R.; Delgado, G.; Alvarez, L.* Bioactive Oleanolic Acid Saponins and Other Constituents from the Roots of Viguiera Decurrens. Phytochemistry 2001, 56 (1), 93–97. DOI: 10.1016/S0031-9422(00)00283-1

2. Ortega, A.*; Garcı́a, P. E.; Cárdenas, J.; Mancera, C.; Marquina, S.; del Carmen Garduño, M. L.; Maldonado, E. Methyl Dodonates, a New Type of Diterpenes with a Modified Clerodane Skeleton from Dodonaea Viscosa. Tetrahedron 2001, 57 (15), 2981–2989. DOI: 10.1016/S0040-4020(01)00161-2

1. Garduño-Ramírez, M. L.; Trejo, A.; Navarro, V.; Bye, R.; Linares, E.; Delgado, G.* New Modified Eremophilanes from the Roots of Psacalium R Adulifolium. J. Nat. Prod. 2001, 64 (4), 432–435. DOI: 10.1021/np000385z



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