PH-Fernández Zertuche Mario
Mario Fernández Zertuche

Doctorado en Química, Universidad de California, Irvine (1987)
Profesor: Titular C
SNI: Nivel II
Líneas de Investigación: Síntesis orgánica y química medicinal
Cuerpo Académico: Síntesis Orgánica
mfz@uaem.mx| Teléfono: +52 777 329 79 97 Ext.6012
2018

34. Rodríguez-Lozada, J.; Tovar-Gudiño, E.; Guevara-Salazar, J.; Razo-Hernández, R.; Santiago, Á.; Pastor, N.; Fernández-Zertuche, M.* QSAR and Molecular Docking Studies of the Inhibitory Activity of Novel Heterocyclic GABA Analogues over GABA-AT. Molecules 2018, 23 (11), 2984. DOI: 10.3390/molecules23112984

33. Tovar-Gudiño, E.; Guevara-Salazar, J.; Bahena-Herrera, J.; Trujillo-Ferrara, J.; Martínez-Campos, Z.; Razo-Hernández, R.; Santiago, Á.; Pastor, N.; Fernández-Zertuche, M.* Novel-Substituted Heterocyclic GABA Analogues. Enzymatic Activity against the GABA-AT Enzyme from Pseudomonas Fluorescens and In Silico Molecular Modeling. Molecules 2018, 23 (5), 1128. DOI: 10.3390/molecules23051128

2016

 32. Flores-Romero, J. D.; Rodríguez-Lozada, J.; López-Ortiz, M.; Magaña, R.; Ortega-Blake, I.; Regla, I.*; Fernández-Zertuche, M.* Multigram Scale Synthesis of A21, A New Antibiotic Equally Effective and Less Toxic than Amphotericin B. Org. Process Res. Dev. 2016, 20 (8), 1529–1532. DOI: 10.1021/acs.oprd.6b00211

31. Antillón, A.; de Vries, A. H.; Espinosa-Caballero, M.; Falcón-González, J. M.; Romero, D. F.; González–Damián, J.; Jiménez-Montejo, F. E.; León-Buitimea, A.; López-Ortiz, M.; Magaña, R.; Marrink Siewert J.; Morales-Nava R.; Periole X.; Reyes-Esparza J.; Rodríguez Lozada J.; Santiago-Angelino T.; Vargas González M.; Regla I.; Carrillo-Tripp M.; Feranández-Zertuche M.; Rodríguez-Fragoso L.; Ortega- Blake I.;* An Amphotericin B Derivative Equally Potent to Amphotericin B and with Increased Safety. PLoS One 2016, 11 (9), e0162171. DOI: 10.1371/journal.pone.0162171

30. de la Cruz-Cordero, R.; Labastida-Galván, V.; Fernández-Zertuche, M.; Ordóñez, M.* Preparation of Phosphostatine Analogues From L-Amino Acids. 2016. Online: http://ri.uaemex.mx/handle/20.500.11799/39328

29. Loredo-Calderón, E. L.; López-Cortina, S. T.*; Carranza-Rosales, P.; Viveros-Valdez, E.; Hernández-Fernández, E.; Fernández-Zertuche, M. Synthesis and Characterization of Six Nonsymmetric A3B Porphyrins with P-Chlorophenyl as Meso-Substituent A or B and Determination of Their Photodynamic Activity. Med. Chem. Res. 1–9. DOI: 10.1007/s00044-016-1600-4

2014

28. Morales-Nava, R.; Ramírez-Solís, A.; Fernández-Zertuche, M.* NMR and Theoretical Studies on the Conformational Preferences of Some Non-Metal Coordinated N-Enoyl Systems Attached to Common Chiral Auxilaries. J. Mex. Chem. Soc. 2014, 58 (2), 89–94. Online http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S1870-249X2014000200001

27. Rodriguez-Lopez, A.; Ortega, I.; Fernandez-Zertuche, M.; Regla, I.; Reyes-Esparza, J.; Rodríguez-Fragoso, L. Evaluation of Safety and Efficacy Antifungal of an Amide Derivative of Amphotericin B as Scaling Product on in Vitro Models (844.12). FASEB J. 2014, 28 (1 Supplement), 812–844. Online http://www.fasebj.org/content/28/1_Supplement/844.12.short

2013

26. Tovar-Gudiño, E.; Morales-Nava, R.; Fernández-Zertuche, M.* Diasteroselective Conjugate Addition of Diethylaluminum Cyanide to a Conjugated N-Enoyl System: An Alternative Synthesis of (S)-Pregabalin. Can. J. Chem. 2013, 92 (1), 45–48. DOI: 10.1139/cjc-2013-0397

2011

25. López Cortina, S.*; Elizondo Martínez, P.; Pérez Rodríguez, N.; Hernández Fernández, E.; Fernández Zertuche, M. Synthesis of 3-OXO-3-Phenyl-2, 2, 5-Trimethyl-1, 3-Oxaphosphorinanes and Their Tetrafluoroborate Salts. Química Hoy 2011, 1 (2), 2–9. Online http://eprints.uanl.mx/9796/1/Synthesis.pdf

24. Balbás, I. M.; Mendoza, B. E. D.; Fernández-Zertuche, M.; Ordoñez, M.; Linzaga-Elizalde, I.* Synthesis of Cis-and Trans-3-Aminocyclohexanols by Reduction of β-Enaminoketones. Molecules 2012, 17 (1), 151–162. DOI: 10.3390/molecules17010151

23. Morales-Nava, R.; Fernández-Zertuche, M.*; Ordóñez, M. Microwave-Assisted Improved Synthesis of Oxazolidin-2-Ones, Oxazolidine-2-Thiones and Thiazolidine-2-Thione Chiral Auxiliaries. Molecules 2011, 16 (10), 8803–8814. DOI: 10.3390/molecules16108803

2010

22. León-Buitimea, A.; Morales-Nava, R.; Fernández-Zertuche, M.; Ortega-Blake, I.; Reyes-Esparza, J.; Rodriguez-Fragoso, L. Pharmacological and Toxicological Study of Two Analogues of Amphotericin by Using in Vitro Models. FASEB J. 2010, 24 (1 Supplement), 961–964. Online http://www.fasebj.org/content/24/1_Supplement/964.1.short

21.López-Cortina, S.; Medina-Arreguin, A.; Hernández-Fernández, E.; Bernès, S.; Guerrero-Alvarez, J.; Ordoñez, M.; Fernández-Zertuche, M.* Stereochemistry of Base-Induced Cleavage of Methoxide Ion on Cis-and Trans-1, 4-Diphenylphosphorinanium Salts. A Different Behavior with a Phenyl Substituent. Tetrahedron 2010, 66 (32), 6188–6194. DOI: 10.1016/j.tet.2010.05.095

2007

20. Poo, J. L.*; Gongora, J.; Sanchez-Avila, J. F.; Aguilar-Castillo, S.; Ramos, G. G.; Fernandez-Zertuche, M.; Rodriguez-Fragoso, L.; Uribe, M. [81] Efficacy and safety of l-ornithine-l-aspartate (lola) administration. open label randomized controlled trial versus lactulose in cirrhotic patients with hyperammonemic hepatic encephalopathy. J. Hepatol. 2007, 46, S36. DOI: 10.1016/S0168-8278(07)61679-1

19.Rojas-Cabrera, H.; Ochoa-Morales, J.; Hernández-Núñez, E.; Fernández Zertuche, M.; Ordóñez, M.* Efficient and Practical Synthesis of Syn-and Anti-Β, Υ-Dihydroxyphosphonates Derived from (S)-Mandelic Acid. J. Mex. Chem. Soc. 2007, 51 (4), 237–244. Online http://www.scielo.org.mx/scielo.php?pid=S1870-249X2007000400013&script=sci_arttext

18.Rojas-Cabrera, H.; Fernández-Zertuche, M.; García-Barradas, O.; Muñoz-Muñiz, O.; Ordóñez, M.* Preparation of Dimethyl (R)-and (S)-2-(2-Hydroxyphenyl)-2-Hydroxyethylphosphonate Derived from Salicylaldehyde via Resolution Using (S)-Methoxyphenylacetic Acid (MPA). Tetrahedron: Asymmetry 2007, 18 (1), 142–148. DOI: 10.1016/j.tetasy.2006.12.022

17.Ordóñez, M.*; Hernández-Fernández, E.; Montiel-Pérez, M.; Bautista, R.; Bustos, P.; Rojas-Cabrera, H.; Fernández-Zertuche, M.; García-Barradas, O. A Convenient Method for the Preparation of Chiral Phosphonoacetamides and Their Horner–Wadsworth–Emmons Reaction. Tetrahedron: Asymmetry 2007, 18 (20), 2427–2436. DOI: 10.1016/j.tetasy.2007.09.033

2006

16.Hernández-Fernández, E.; Fernández-Zertuche, M.; García-Barradas, O.; Muñoz-Muñiz, O.; Ordóñez, M.* Practical and Efficient Synthesis of (E)-Α, β-Unsaturated Amides Bearing (S)-α-Methylbenzylamine from 2-Phosphonamides via Horner-Wadsworth-Emmons Reaction. Synlett 2006, 2006 (3), 440–444. Online https://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2006-926265.pdf

15. Poo, J. L.*; Góngora, J.; Sánchez-Ávila, F.; Aguilar-Castillo, S.; García-Ramos, G.; Fernández-Zertuche, M.; Rodríguez-Fragoso, L.; Uribe, M. Efficacy of Oral L-Ornithine-L-Aspartate in Cirrhotic Patients with Hyperammonemic Hepatic Encephalopathy. Results of a Randomized, Lactulose-Controlled Study. Ann Hepatol 2006, 5 (4), 281–288. Online http://www.medigraphic.com/pdfs/hepato/ah-2006/ah064i.pdf

2005

14. De la Cruz-Cordero, R.; Hernándes-Núñez, E.; Fernández-Zertuche, M.; Muñoz-Hernández, M. A.; Ordóñez, M.* Preparation of Phosphostatine and Phosphoepistatine from L-Leucine via High Diastereoselective Reduction of 3-Amino-2-Ketophosphonates. ARKIVOC 2005, 6, 277–286. DOI: 10.3998/ark.5550190.0006.623

13.López-Cortina, S.; Basiulis, D. I.; Marsi, K. L.; Muñoz-Hernández, M. A.; Ordonez, M.; Fernández-Zertuche*, M. Synthesis of New 1, 3-Oxaphosphorinanium Salts. Stereochemistry of Hydroxide-Induced Displacement of Methoxide Ion. J. Org. Chem. 2005, 70 (19), 7473–7478. DOI: 10.1021/jo050901w

12.Meza-Aviña, M. E.; Ordoñez, M.; Fernández-Zertuche, M.*; Rodríguez-Fragoso, L.; Reyes-Esparza, J.; de los Ríos, A. A. M. Synthesis of Some Monocyclic Analogues of Mycophenolic Acid via the Johnson Ortho Ester Claisen Rearrangement. Bioorg. Med. Chem. 2005, 13 (23), 6521–6528. DOI: 10.1016/j.bmc.2005.07.013

2004

11.González-Morales, A.; Fernández-Zertuche, M.; Ordóñez, M.* Simultaneous Separation and Assignment of Absolute Configuration of γ-Amino-β-Hydroxyphosphonates by NMR Using (S)-Methoxyphenylacetic Acid (MPA). Rev. Soc. Quím. Méx 2004, 48, 239–245. Online: http://www.redalyc.org/pdf/475/47548406.pdf

10. González-Morales, A.; Dı́az-Coutiño, D.; Fernández-Zertuche, M.; Garcı́a-Barradas, O.; Ordóñez, M.* Preparation of Dimethyl (R)-and (S)-2-(2-Aminophenyl)-2-Hydroxyethylphosphonate from Anthranilic Acid. Tetrahedron: Asymmetry 2003, 15 (3), 457–463. DOI: 10.1016/j.tetasy.2003.11.038

9. Ordóñez, M.*; De la Cruz-Cordero, R.; Fernández-Zertuche, M.; Muñoz-Hernández, M. A.; García-Barradas, O. Diastereoselective Reduction of Dimethyl γ-[(N-P-Toluenesulfonyl) Amino]-β-Ketophosphonates Derived from Amino Acids. Tetrahedron: Asymmetry 2004, 15 (19), 3035–3043. DOI: 10.1016/j.tetasy.2004.08.012

2003

8. Fernández-Zertuche, M.*; López-Cortina, S.; Meza-Aviña, M. E.; Ordóñez, M.; Ramírez-Solís, A. Generation of Alkoxyalkynylketenes from a Bicyclic Precursor. Cycloaddition Chemistry with Alkynes and Theoretical Studies Regarding the Formation of Five-versus Six-Membered Ring Products. ARKIVOC 2003, 11, 89–99. Online http://www.arkat-usa.org/get-file.php?fileid=20025

7. Flores-Morales, V.; Fernández-Zertuche, M.*; Ordóñez, M.* Highly Diastereoselective Addition of Et 2 AlCN to β-Keto Amides Derived from (S)-4-Isopropyl-2-Oxazolidinone. Tetrahedron: Asymmetry 2003, 14 (18), 2693–2698. DOI: 10.1016/j.tetasy.2003.07.004

6. Ordóñez, M.*; González-Morales, A.; Ruı́z, C.; De la Cruz-Cordero, R.; Fernández-Zertuche, M. Preparation of (R)-and (S)-γ-Amino-β-Hydroxypropylphosphonic Acid from Glycine. Tetrahedron: Asymmetry 2003, 14 (13), 1775–1779. DOI: 10.1016/S0957-4166(03)00371-9

2002

5. Ordonez, M.*; de la Gruz, R.; Fernandez‐Zertuche, M.; Munoz‐Hernandez, M. Diastereoselective Reduction of β‐Ketophosphonates Derived from Amino Acids. A New Entry to Enantiopure β‐Hydroxy‐γ‐aminophosphonate Derivatives. Thetrahedrom Asymmetry 2002, 13 (66), 559-562. DOI: 10.1016/S0957-4166(02)00159-3

4. Ordóñez, M.; De la Cruz-Cordero, R.; Fernández-Zertuche, M.; Muñoz-Hernández, M. A. Diastereoselective Reduction of γ-N, N-Dibenzylamino-β-Ketophosphonates γ-Substituted. Tetrahedron: Asymmetry 2002, 13, 559–562. PDF

3. Fernández-Zertuche, M.*; Robledo-Pérez, R.; Meza-Aviña, M. E.; Ordoñez-Palacios, M. Allylic Strain Effects on the Stereochemistry of the Alkylation Reaction of Mycophenolic Acid Chiral Enolates. Tetrahedron Lett. 2002, 43 (20), 3777–3780. DOI: 10.1016/S0040-4039(02)00469-0

2. Ordóñez, M./*; de la Cruz, R.; Fernández-Zertuche, M.; Muñoz-Hernández, M.-Á. Diastereoselective Reduction of β-Ketophosphonates Derived from Amino Acids. A New Entry to Enantiopure β-Hydroxy-γ-Aminophosphonate Derivatives. Tetrahedron: Asymmetry 2002, 13 (6), 559–562. DOI: 10.1016/S0957-4166(02)00159-3

2000

1. Fernández-Zertuche, M.*; Hernández-Lamoneda, R.; Ramírez-Solís, A. Cyclic Allenes or Diradicals in the Cyclization Reactions of Dienynes Generated by Photolysis of Alkynylcyclohexadienones. J. Org. Chem. 2000, 65 (17), 5207–5211. DOI: 10.1021/jo000333e


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