Escalante García Jaime

Jaime Escalante García

Doctorado en Química Orgánica, CINVESTAV-IPN (1995)

Profesor: Titular C

SNI: Nivel II

Líneas de Investigación: 

  • Química Orgánica.
  • Desarrollo de nuevas metodologías sintéticas en la producción de aminoácidos.
  • Difracción de Rayos X.
  • Análisis Conformacional de Moléculas Orgánicas.
  • Reconocimiento enzimático.
  • Síntesis Asimétrica.
  • Síntesis de linkers para la formación de nanoestructuras con aplicación biológica.

Laboratorio de Sintésis Asimétrica

Cuerpo Académico: Química Farmacéutica y Biotecnología

jaime@uaem.mx |Teléfono: +52 777 329 79 97 Ext. 6040

ORCID: 0000-0001-5485-0244| Scopus Author ID: 7003360738

Google Académico 


2024

78. Flores-Hernández, F., Zárate-López, T. I., Alcaráz-Cano, M. A., Escalante, J., & Rivera-Ramírez, J. D. (2024). Podophyllotoxin and Aryltetralin Lignans: Methods for the Synthesis of Rings A, B, C, D. Journal of Organic and Pharmaceutical Chemistry, 22(2), 3–25. https://doi.org/10.24959/ophcj.24.308942



77. Chavelas-Hernández, Leticia y Hernández-Vázquez, Luis G. y Valdez-Camacho, Jonathan R. y Espinoza-Guillén, Adrián y Tavira-Montalván, Carlos A. y Meneses-Acosta, Angélica y Juaristi, Eusebio y Ruiz-Azuara, Lena y Escalante, Jaime, Síntesis de complejos de nitrato de cobre (1,10-fenantrolina- K 2 N ,N')(Β 2 -metil- y Β 2 -fenilalaninato- K 2 N ,O) y su actividad antiproliferativa en las líneas celulares de cáncer Mcf-7 y A549. Disponible en SSRN: https://ssrn.com/abstract=4758164 o http://dx.doi.org/10.2139/ssrn.4758164


75. Bahena‐Martínez, J. D., Flores, R., Domínguez‐Mendoza, B. E., Hernández‐Vázquez, L. G., Juaristi, E., & Escalante, J*. (2024). Synthesis of β‐Truxinate via [2+2] Cycloaddition of Methyl 4‐Nitrocinnamate: Kinetic Study of its Isomerization with DBU. ChemistrySelect, 9(22). https://doi.org/10.1002/slct.202400178


2023

74. Guzmán-Ávila, R., Estrada-Soto, S*., Arias-Durán, L., Millán-Pacheco, C., Escalante-García, J., Rios, M. Y., Flores-Morales, V., Villalobos-Molina, R., & Pérez-Barrón, G. (2023). Vasorelaxant and Antihypertensive Effects of (3β)-ursen-12-en-3,28-diol by NO/cGMP System. Letters in Drug Design & Discovery, 20(12), 1959–1969. DOI: 10.2174/1570180819666220704111424


73.  Chavelas-Hernández, L., Hernández-Vázquez, L. G., Bahena-Martínez, J. D., Arroyo-Colín, A. B., Flores-Osorio, S. G., Navarrete-Vázquez, G., & Escalante, J. (2023). Aza-Michael Additions of Benzylamine to Acrylates Promoted by Microwaves and Conventional Heating Using DBU as Catalyst via Solvent-Free Protocol. Processes, 12(1), 34. DOI: 10.3390/pr12010034


72.  Romero-Ibañez, J., Ortega-Rojas, M. A., Valdéz-Camacho, J. R., Hernández-Vázquez, L. G., Sartillo-Piscil, F., & Escalante, J.* (2023). Asymmetric Synthesis of trans-3-Alkoxyamino-4-Oxygenated-2-Piperidones Mediated by Transition-Metal-Free Dual C-H Oxidation and Its CAL-B-Assisted Enzymatic Resolution. Catalysts, 13(4), 703. DOI: 10.3390/catal13040703


2022

71. Sánchez‐Muñoz, G. K.; Ortega‐Rojas, M. A*.; Chavelas‐Hernández, L.; Razo‐Hernández, R. S.; Valdéz‐Camacho, J. R.; Escalante, J*. Solvent‐Free Lipase‐Catalyzed Transesterification of Alcohols with Methyl Esters Under Vacuum‐Assisted Conditions. ChemistrySelect 2022, 7 (30). DOI: 10.1002/slct.202202643.


2021

70. Ortega‐Rojas, M. A.; Castillo, E*.; Razo‐Hernández, R. S.; Pastor, N.; Juaristi, E.; Escalante, J.* Effect of the Substituent and Amino Group Position on the Lipase‐Catalyzed Resolution of γ‐Amino Esters: A Molecular Docking Study Shedding Light on Candida Antarctica Lipase B Enantioselectivity. European J. Org. Chem. 2021, 2021 (34), 4790–4802. DOI: 10.1002/ejoc.202100712


2020

69. Méndez, A.; Valdez-Camacho, J. R.; Escalante, J.* Photooxidation of 2-(Tert-Butyl)-3-Methyl-2,3,5,6,7,8-Hexahydroquinazolin-4(1H)-One, an Example of Singlet Oxygen Ene Reaction. Molecules 2020, 25 (21), 5008 DOI: 10.3390/molecules25215008


68. Valdéz-Camacho, J. R., Ramírez-Solís, A., Escalante, J., Ruiz-Azuara, L., & Hô, M.* (2020). Theoretical determination of half-wave potentials for phenanthroline-, bipyridine-, acetylacetonate-, and glycinate-containing copper (II) complexes. Journal of Molecular Modeling, 26(7), 191. https://doi.org/10.1007/s00894-020-04453-x

ARTÍCULOS EN REVISTAS INDEXADAS

2023

72. Romero-Ibañez, J., Ortega-Rojas, M. A., Valdéz-Camacho, J. R., Hernández-Vázquez, L. G., Sartillo-Piscil, F., & Escalante, J.* (2023). Asymmetric Synthesis of trans-3-Alkoxyamino-4-Oxygenated-2-Piperidones Mediated by Transition-Metal-Free Dual C-H Oxidation and Its CAL-B-Assisted Enzymatic Resolution. Catalysts, 13(4), 703. DOI: 10.3390/catal13040703


2022

71. Sánchez‐Muñoz, G. K.; Ortega‐Rojas, M. A*.; Chavelas‐Hernández, L.; Razo‐Hernández, R. S.; Valdéz‐Camacho, J. R.; Escalante, J*. Solvent‐Free Lipase‐Catalyzed Transesterification of Alcohols with Methyl Esters Under Vacuum‐Assisted Conditions. ChemistrySelect 2022, 7 (30). DOI: 10.1002/slct.202202643.


2021

70. Ortega‐Rojas, M. A.; Castillo, E*.; Razo‐Hernández, R. S.; Pastor, N.; Juaristi, E.; Escalante, J.* Effect of the Substituent and Amino Group Position on the Lipase‐Catalyzed Resolution of γ‐Amino Esters: A Molecular Docking Study Shedding Light on Candida Antarctica Lipase B Enantioselectivity. European J. Org. Chem. 2021, 2021 (34), 4790–4802. DOI: 10.1002/ejoc.202100712


2020

69. Méndez, A.; Valdez-Camacho, J. R.; Escalante, J.* Photooxidation of 2-(Tert-Butyl)-3-Methyl-2,3,5,6,7,8-Hexahydroquinazolin-4(1H)-One, an Example of Singlet Oxygen Ene Reaction. Molecules 2020, 25 (21), 5008 DOI: 10.3390/molecules25215008


68. Valdéz-Camacho, J. R., Ramírez-Solís, A., Escalante, J., Ruiz-Azuara, L., & Hô, M.* (2020). Theoretical determination of half-wave potentials for phenanthroline-, bipyridine-, acetylacetonate-, and glycinate-containing copper (II) complexes. Journal of Molecular Modeling, 26(7), 191. https://doi.org/10.1007/s00894-020-04453-x


67. Valdez-Camacho, J. R.; Pérez-Salgado, Y.; Espinoza-Guillén, A.; Gómez-Vidales, V.; Alberto Tavira-Montalvan, C.; Meneses-Acosta, A.; Leyva, M. A.; Vázquez-Ríos, M. G.; Juaristi, E.; Höpfl, H.; Ruiz-Azuara, L.; Escalante, J.* Synthesis, Structural Characterization and Antiproliferative Activity on MCF-7 and A549 Tumor Cell Lines of [Cu(N-N)(Β3-Aminoacidate)]NO3 Complexes (Casiopeínas®). Inorganica Chim. Acta 2020, 506, 119542 DOI: 10.1016/j.ica.2020.119542


2019

66. Chavelas-Hernández, L.; Valdéz-Camacho, J. R.; Hernández-Vázquez, L. G.; Dominguez-Mendoza, B. E.; Vasquez-Ríos, M. G.; Escalante, J.* A New Approach Using Aromatic-Solvent-Induced Shifts in NMR Spectroscopy to Analyze β-Lactams with Various Substitution Patterns. Synlett 2019 DOI: 10.1055/s-0039-1691498


65. Álvarez-Santamaría, L.; Juaristi, E.; Arroyo-Colín, A. B.; Palma-Flores, J.; Cabrera-Rivera, F. A.; Escalante, J.* Efficient Solvent-Free Preparation of Imines, and Their Subsequent Oxidation with ≪I≫M≪/I≫-CPBA to Afford Oxaziridines. Green Sustain. Chem. 2019, 09 (04), 143–154 DOI: 10.4236/gsc.2019.94011


64. Valdez‐Camacho, J. R.; Cortés‐Guzmán, K. P.; Torres‐Gómez, H.; Flores, R.; Leyva, M. A.; Escalante, J.* Kinetics, Thermodynamics, and Theoretical Studies in a Diels‐Alder Dimerization Process of 3‐Vinylindole Derivative of the 3‐Indoleacetic Acid: An Auxin. ChemistrySelect 2019, 4 (28), 8311–8316. DOI: 10.1002/slct.201901141


63. Morales-Vilchis, M. G.; Flores-Sánchez, P.; Escalante, J. Identification, Synthesis and Structure Assignment of Two Impurities of Erlotinib, a Drug Used for the Treatment of Some Types of Cancer. J. Mex. Chem. Soc. 2019, 63 (1) DOI: 10.29356/jmcs.v63i1.714


62. Valdéz-Camacho, J. R.; Rivera-Ramírez, J. D.; Escalante, J.* Studies and Mechanism of Olefination Reaction in Aryl-Enolates with Paraformaldehyde. Int. J. Org. Chem. 2019, 09 (01), 10–22. DOI: 10.4236/ijoc.2019.91002


2017

61. Cabrera-Rivera, F. A.; Hernández-Vázquez, L. G.; Flores-Sánchez, P.; Durán-Galván, M.; Escalante, J.* Solvent- and Catalyst-Free Microwave-Assisted Decarboxylation of Malonic Acid Derivatives. Green Sustain. Chem. 2017, 7 (4), 270–280. DOI: 10.4236/gsc.2017.74021


60. Ortega-Rojas, M.; Rivera-Ramírez, J.; Ávila-Ortiz, C.; Juaristi, E.*; González-Muñoz, F.; Castillo, E.*; Escalante, J.* One-Pot Lipase-Catalyzed Enantioselective Synthesis of (R)-(−)-N-Benzyl-3-(Benzylamino)butanamide: The Effect of Solvent Polarity on Enantioselectivity. Molecules 2017, 22 (12), 2189. DOI: 10.3390/molecules22122189


59. Pérez-Venegas, M.; Reyes-Rangel, G.; Neri, A.; Escalante, J.*; Juaristi, E.* Mechanochemical Enzymatic Resolution of N -Benzylated-β 3 -Amino Esters. Beilstein J. Org. Chem. 2017, 13, 1728–1734. DOI: 10.3762/bjoc.13.167


2016

58. Torres-Huerta, A.; Cruz-Huerta, J.; Höpfl, H.*; Hernández-Vázquez, L. G.; Escalante-García, J.; Jiménez-Sánchez, A.; Santillan, R.; Hernández-Ahuactzi, I. F.; Sánchez, M. Variation of the Molecular Conformation, Shape, and Cavity Size in Dinuclear Metalla-Macrocycles Containing Hetero-Ditopic Dithiocarbamate–Carboxylate Ligands from a Homologous Series of N-Substituted Amino Acids. Inorg. Chem. 2016. DOI: 10.1021/acs.inorgchem.6b02387


57. Rosas-Valdéz, M. E.; Escalante, J.*; Bustos-Jaimes, I.; Regla, I.; Boto, A. Synthesis and Modification of the Amyloid Peptide Sequence 37-42 of Aβ42 (AβPP): Efficient Synthesis of N-Methylated Peptides, Expanding the Tools for Peptide Research. J. Mex. Chem. Soc. 2016, 60 (3), 125–134. Online 


56. Boto, A.; Escalante, J. 1‐(Trimethylsilyl)‐1H‐benzotriazole. e-EROS Encycl. Reagents Org. Synth. DOI: 10.1002/047084289X.rn01189


2015

55. Rangel, H.; Carrillo-Morales, M.; Galindo, J. M.; Castillo, E.; Obregón-Zúñiga, A.; Juaristi, E.; Escalante, J.* Structural Features of N-Benzylated-β-Amino Acid Methyl Esters Essential for Enantiodifferentiation by Lipase B from Candida Antarctica in Hydrolytic Reactions. Tetrahedron: Asymmetry 2015, 26 (7), 325–332. DOI: 10.1016/j.tetasy.2015.02.007


54. Rivera-Ramírez, J. D.; Escalante, J.*; López-Munguía, A.; Marty, A.; Castillo, E.* Thermodynamically Controlled Chemoselectivity in Lipase-Catalyzed Aza-Michael Additions. J. Mol. Catal. B Enzym. 2015, 112, 76–82. DOI: 10.1016/j.molcatb.2014.12.009


2014

53. Cabrera-Rivera, F. A.; Escalante, J.* Synthesis, Resolution and Absolute Configuration of 2, 3-Dihydro-2-Tert-Butyl-3-N-Benzylquinazolin-4-One: A Possible Chiral Auxiliary for Synthesis of β-Amino Cyclohexancarboxylic Acid. Int. J. Org. Chem. 2014, 2014. DOI: 10.4236/ijoc.2014.41007


52. Robledo, N.*; Vega, M.; Escalante, J.; Arzuffi, R. A New Component of the Male Papaya Fruit Fly (Diptera: Tephritidae) Sex Pheromone. Florida Entomol. 2014, 97 (3), 1260–1262. DOI: 10.1653/024.097.0338


51. Del-Oso, J.-A.; Maldonado, J.-L.*; Ramos-Ortíz, G*.; Rodríguez, M.; Güizado-Rodríguez, M.*; Escalante, J.; Frontana-Uribe, B. A.; Pérez-Gutiérrez, E.; Santillan, R. New Polythiophene Derivatives and Enhanced Photovoltaic Effect by a Boron Compound Blended with Them in OPVs Cells. Synth. Met. 2014, 196, 83–91. DOI: 10.1016/j.synthmet.2014.07.019


50. Cabrera-Rivera, F. A.; Escalante, J.*; Morales-Rojas, H.; Zigler, D. F.; Schmidt, R. D.; Jarocha, L. E.; Forbes, M. D. E.* Photophysical Properties of 2, 3-Dihydroquinazolin-4 (1H)-One Derivatives. J. Photochem. Photobiol. A Chem. 2014, 294, 31–37. DOI: 10.1016/j.jphotochem.2014.07.005


2012

49. Cervantes Cuevas, H.*; García Martínez, C.; Escalante García, J. Reacción de N, N’-bis (2-Heteroaril) Etilendiaminas Con Aldehídos, Nuevas Imidazolidinas. Rev. Latinoam. química 2012, 40 (3), 187–198. Online 


48. Navarrete-Vazquez.*;  Ramírez-Martínez, M., Estrada-Soto, S., Nava-Zuazo, C., Paoli, P., Camici, G., Escalante-García, J., (...), Ortiz-Andrade, R., G. Synthesis, in Vitro and in Silico Screening of Ethyl 2-(6-Substituted Benzo[d]thiazol-2-Ylamino)-2-Oxoacetates as Protein-Tyrosine Phosphatase 1B Inhibitors. Eur. J. Med. Chem. 2012, 53, 346–355. DOI: 10.1016/j.ejmech.2012.04.025


47. Hernández‐Vázquez, L. G.; Leyva, M. A.; Metta‐Magaña, A. J.; Escalante, J.* Microwave‐Assisted Synthesis of β‐Lactams and Cyclo‐β‐dipeptides. Helv. Chim. Acta 2012, 95 (11), 2218–2230. DOI: 10.1002/hlca.201200449


46. Cabrera-Rivera, F. A.; Ortíz-Nava, C.; Escalante, J.*; Hernández-Pérez, J. M.; Hô, M. Photoinduced Elimination in 2, 3-Dihydro-2-Tert-Butyl-3-Benzyl-4 (1H)-Quinazolinone: Theoretical Calculations and Radical Trapping Using TEMPO Derivatives. Synlett 2012, 23 (7), 1057–1063. DOI: 10.1055/s-0031-1290492


45. Sandoval-González, A.; Borja-Arco, E.; Escalante, J.; Jiménez-Sandoval, O.; Gamboa, S. A.* Methanol Oxidation Reaction on PtSnO 2 Obtained by Microwave-Assisted Chemical Reduction. Int. J. Hydrogen Energy 2012, 37 (2), 1752–1759. DOI: 10.1016/j.ijhydene.2011.10.049


44. Cabrera-Rivera, F. A.; Ortíz-Nava, C.; Román-Bravo, P.; Leyva, M. A.; Escalante, J.* Direct Halogenation Reactions in 2, 3-Dihydro-4 (1H)-Quinazolinones. Heterocycles 2012, 85 (9), 2173. DOI: 10.3987/COM-12-12473


2011

43. Borja-Arco, E.*; Jiménez-Sandoval, O.; Escalante-García, J.; Magallón-Cacho, L.; Sebastian, P. J.* Microwave Assisted Synthesis of Osmium Electrocatalysts for the Oxygen Reduction Reaction in the Absence and Presence of Aqueous Methanol. Int. J. Electrochem. 2011, 2011. DOI: 10.4061/2011/830541


42. Borja-Arco, E.; Sandoval, O. J.; Escalante-García, J.; Sandoval-González, A.; Sebastian, P. J.* Microwave Assisted Synthesis of Ruthenium Electrocatalysts for Oxygen Reduction Reaction in the Presence and Absence of Aqueous Methanol. Int. J. Hydrogen Energy 2011, 36 (1), 103–110. DOI: 10.1016/j.ijhydene.2010.10.051


41. Garcia-Martinez, C.*; Cervantes, H.; Mendez, F.; Escalante, J. Stoichiometry, Association Constant, and Solvation Model of Chiral Hydroxyfuranones in the Presence of Pirkle’s Alcohols. Spectrosc. Lett. 2011, 44 (3), 168–175. DOI: 10.1080/00387010.2010.489096


40. Nicho, M. E.*; Medrano-Baca, M. G.; León-Silva, U.; Escalante, J.; González-Rodríguez, G.; Güizado-Rodríguez, M.; Linzaga-Elizalde, I. Effect of Adhesion Promoter in Corrosion Protection of 1018 Mild Steel by Using Poly (3-Hexylthiophene) Coatings in 0.5 M H2SO4 Solution. Corros. J. Sci. Eng. 2011, 67 (10), 105002. DOI: 10.5006/1.3647763


2010

39. Güizado-Rodríguez, M.*; López-Tejeda, M.; Escalante, J.; Guerrero-Álvarez, J. A.; Nicho, M. E. Photosensitive Polyaniline Colloidal Particles Prepared by Enzymatic Polymerization Using the Azopolymer DMA-Co-AZAAm as Stabilizer. Mater. Chem. Phys. 2010, 124 (1), 389–394. DOI: 10.1016/j.matchemphys.2010.06.052


38. Miranda-Molina, A.; López-Munguía, A.; San Román, M. L.; Escalante, J.; Leyva, M. A.; Puebla, A. M.; Castillo, E.*; Álvarez, L.* Stereoselective Enzymatic Synthesis of Monoglucosyl-Myo-Inositols with in Vivo Anti-Inflammatory Activity. Tetrahedron: Asymmetry 2010, 21 (1), 43–50. DOI: 10.1016/j.tetasy.2009.12.009


2009

37. Robledo, N.; Escalante, J.*; Arzuffi, R. Extraction with SPME and Synthesis of 2-Methyl-6-Vinylpyrazine by a “One Pot”reaction Using Microwaves. Molecules 2009, 14 (6), 2160–2166. DOI: 10.3390/molecules14062160


36. Díaz-Coutiño, F. D.; Escalante, J.* Efficient ’One Pot’ Nitro Reduction-Protection of γ-Nitro Aliphatic Methyl Esters. J. Mex. Chem. Soc. 2009, 53 (3), 93–95. Online 


35. Escalante, J.*; Díaz-Coutiño, F. D. Synthesis of γ-Nitro Aliphatic Methyl Esters via Michael Additions Promoted by Microwave Irradiation. Molecules 2009, 14 (4), 1595–1604. DOI: 10.3390/molecules14041595


34. Priego, J.; Ortíz-Nava, C.; Carrillo-Morales, M.; López-Munguía, A.; Escalante, J.*; Castillo, E.* Solvent Engineering: An Effective Tool to Direct Chemoselectivity in a Lipase-Catalyzed Michael Addition. Tetrahedron 2009, 65 (2), 536–539. DOI: 10.1016/j.tet.2008.10.103


33. Linzaga-Elizalde, I.*; Escalante, J.; Nicho, M. E.; Güizado-Rodríguez, M. Synthesis of 2-(Thiophen-3-Yl) Vinylphosphonic Acid. Synth. Commun. 2009, 39 (9), 1511–1515. DOI: 10.1080/00397910902784462


32. Marquina, S.; Parra, J. L.; González, M.; Zamilpa, A.; Escalante, J.; Trejo-Hernández, M. R.; Álvarez, L.* Hydroxylation of the Diterpenes Ent-Kaur-16-En-19-Oic and Ent-Beyer-15-En-19-Oic Acids by the Fungus Aspergillus Niger. Phytochemistry 2009, 70 (17), 2017–2022. DOI: 10.1016/j.phytochem.2009.09.005


31. Pérez-Picaso, L.; Escalante, J.; Olivo, H. F.; Rios, M. Y.* Efficient Microwave Assisted Syntheses of 2,5-Diketopiperazines in Aqueous Media. Molecules 2009, 14 (8), 2836–2849. DOI: 10.3390/molecules14082836


2008

30. Escalante, J. Enzymatic Resolution of β‐Amino Methyl Esters Using Lipase B from Candida Antarctica. In recent developments in physical chemistry: third mexican meeting on mathematical and experimental physics; AIP Publishing, 2008; Vol. 979, pp 60–67. DOI:10.1063/1.2901848


29. Escalante, J.*; Carrillo-Morales, M.; Linzaga, I. Michael Additions of Amines to Methyl Acrylates Promoted by Microwave Irradiation. Molecules 2008, 13 (2), 340–347. DOI: 10.3390/molecules13020340


28. Cruz-Huerta, J.; Carillo-Morales, M.; Santacruz-Juárez, E.; Hernández-Ahuactzi, I. F.; Escalante-García, J.; Godoy-Alcantar, C.; Guerrero-Alvarez, J. A.; Höpfl, H.*; Morales-Rojas, H.; Sánchez, M. Macrocyclic Diorganotin Complexes of γ-Amino Acid Dithiocarbamates as Hosts for Ion-Pair Recognition. Inorg. Chem. 2008, 47 (21), 9874–9885. DOI: 10.1021/ic8007987


2007

27. Escalante, J.*; Ortíz-Nava, C.; Flores, P.; Priego, J. M.; García-Martínez, C.* Synthesis, NMR and Crystallographic Studies of 2-Substituted Dihydroquinazolinones Derived from (S)-Phenylethylamine. Molecules 2007, 12 (2), 173–182. DOI: 10.3390/12020173


26. Torres-Gavilán, A.; Escalante, J.; Regla, I.; López-Munguía, A.; Castillo, E.* “Easy-On, Easy-Off”resolution of Chiral 1-Phenylethylamine Catalyzed by Candida Antarctica Lipase B. Tetrahedron: Asymmetry 2007, 18 (22), 2621–2624. DOI: 10.1016/j.tetasy.2007.10.045


2006

25. García-Martínez, C.*; Pérez-Espino, M. A.; Cervantes-Cuevasl, I. H.; Escalante-García, J. Synthesis of mB—Epoxysulfoxides: Thermodynamic Control in Base—induced Cyclization of Chlorohydrins Derived from a—Chlorobenzyl Phenyl Sulfoxide and Alkyl Aldehydes. 2006. Online 


24. Campo, M. A.; Escalante, J.; Sebesta, R. β 2-Amino Acids with Proteinogenic Side Chains and Corresponding Peptides: Synthesis, Secondary Structure, and Biological Activity. EnantioselectiVe Synth. β-Amino Acids 2006, 593–617. DOI: 10.1002/0471698482.ch23 


23. González‐Juárez, E.; Ortega‐Guevara, A.; Linzaga‐Elizalde, I.*; Escalante, J. NMR and X‐ray Crystallographic Studies of Linear and Cyclic Aminomethanephosphinates. Heteroat. Chem. 2006, 17 (2), 81–87. DOI: 10.1002/hc.20179


2005

22. Arvidsson, P. I.; Ryder, N. S.; Weiss, H. M.; Hook, D. F.; Escalante, J.; Seebach, D.* Exploring the Antibacterial and Hemolytic Activity of Shorter-and Longer-Chain B-, A, B-, and G-Peptides, and of B-Peptides from β2 -3-Aza-and b3-2-Methylidene-Amino Acids Bearing Proteinogenic Side Chains-A Survey. Chem. Biodivers. 2005, 2, 401. DOI: 10.1002/cbdv.200590020


21. Flores-Sánchez, P.; Escalante, J.*; Castillo, E. Enzymatic Resolution of N-Protected-β 3-Amino Methyl Esters, Using Lipase B from Candida Antarctica. Tetrahedron: Asymmetry 2005, 16 (3), 629–634. DOI: 10.1016/j.tetasy.2004.11.082


2004

20. Bivián-Castro, E. Y.; Bernes, S.; Escalante, J.; Mendoza-Díaz, G. Chloro (histamine)(1, 10-Phenanthroline) Copper (II) Chloride Monohydrate. Acta Crystallogr. Sect. C Cryst. Struct. Commun. 2004, 60 (5), m205–m207. DOI: 10.1107/S0108270104006560


19. Melgar-Fernandez, R.; Demare, P.; Hong, E.; Rosas, M. A.; Escalante, J.; Munoz-Muniz, O.; Juaristi, E.; Regla, I.* Synthesis and Cardiovascular Activity of Metoprolol Analogues. Bioorg. Med. Chem. Lett. 2004, 14 (1), 191–194. DOI: 10.1016/j.bmcl.2003.09.070


18. Escalante, J.; Flores, P.; Priego, J. M. Synthesis of 2, 3-Dihydro-4 (1H)-Quinazollnones. Heterocycles-Sendai Inst. Heterocycl. Chem. 2004, 63 (9), 2019–2032. Online


17. Priego, J.; Flores, P.; Ortiz-Nava, C.; Escalante, J.* Synthesis of Enantiopure Cis-and Trans-2-Aminocyclohexane-1-Carboxylic Acids from Octahydroquinazolin-4-Ones. Tetrahedron: Asymmetry 2004, 15 (22), 3545–3549. DOI: 10.1016/j.tetasy.2004.08.032


16. Nicho, M. E.*; Hu, H.; López-Mata, C.; Escalante, J. Synthesis of Derivatives of Polythiophene and Their Application in an Electrochromic Device. Sol. Energy Mater. Sol. Cells 2004, 82 (1), 105–118. DOI: 10.1016/j.solmat.2004.01.009


2003

15. García‐Martínez, C.*; Cervantes‐Cuevas, H.; Escalante‐Garcia, J. Synthesis and NMR Configurational Analysis of 1, 3‐imidazolidin‐4‐ones Derived from (−)‐(S)‐phenylethylamine. Chirality 2003, 15 (S1), S74–S81. DOI: 10.1002/chir.10280


14. Escalante, J.*; González-Tototzin, M. A. Synthesis, Resolution and Absolute Configuration of Trans 4, 5-Diphenyl-Pyrrolidin-2-One: A Possible Chiral Auxiliary. Tetrahedron: Asymmetry 2003, 14 (8), 981–985. DOI: 10.1016/S0957-4166(03)00097-1


2002

13. Linzaga, I.; Escalante, J.; Muñoz, M.; Juaristi, E.* NMR and X-Ray Crystallographic Studies of Axial and Equatorial 2-Ethoxy-2-Oxo-1, 4, 2-Oxazaphosphinane. Tetrahedron 2002, 58 (44), 8973–8978. DOI: 10.1016/S0040-4020(02)01152-3


2001

12. Escalante, J.*; Hernández, A. L.; Juaristi, E.* Highly Diastereoselective Addition of a Racemic β-Alanine Enolate Derivative to Electrophiles. Rev. la Soc. 2001, 149 (4), 177–182. Online 


11. Escalante, J.*; González-Tototzin, M. A.; Aviña, J.; Muñoz-Muñiz, O.; Juaristi, E*. Synthesis of β-Lactams and Cyclo-β-Dipeptides from β-Amino Acids: Experimental Observations and Theoretical Analysis. Tetrahedron 2001, 57 (10), 1883–1890. DOI: 10.1016/S0040-4020(00)01169-8


1999

10. Ramírez-Quirós, Y.; Balderas, M.; Escalante, J.; Quintana, D.; Gallardo, I.; Madrigal, D.; Molins, E.; Juaristi, E.* X-Ray Crystallographic Study of Substituted Perhydropyrimidinones. Extreme Changes in Ring Conformation. J. Org. Chem. 1999, 64 (23), 8668–8680. DOI: 10.1021/jo991297q


9. Juaristi, E.*; León-Romo, J. L.; Reyes, A.; Escalante, J. Recent Applications of α-Phenylethylamine (α-PEA) in the Preparation of Enantiopure Compounds. Part 3: α-PEA as Chiral Auxiliary. Part 4: α-PEA as Chiral Reagent in the Stereodifferentiation of Prochiral Substrates. Tetrahedron: Asymmetry 1999, 10 (13), 2441–2495. DOI: 10.1016/S0957-4166(99)00242-6


1998

8. Juaristi, E.*; López-Ruiz, H.; Madrigal, D.; Ramírez-Quirós, Y.; Escalante, J. α-Alkylation of (S)-Asparagine with Self-Regeneration of the Stereogenic Center: Enantioselective Synthesis of α-Substituted Aspartic Acids1, 2. J. Org. Chem. 1998, 63 (14), 4706–4710. DOI: 10.1021/jo980367a


7. Juaristi, E.*; Escalante, J.; León-Romo, J. L.; Reyes, A. Recent Applications of α-Phenylethylamine (α-PEA) in the Preparation of Enantiopure Compounds. Part 1: Incorporation in Chiral Catalysts. Part 2: α-PEA and Derivatives as Resolving Agents. Tetrahedron: Asymmetry 1998, 9 (5), 715–740. DOI: 10.1016/S0957-4166(98)00058-5


1997

6. Crich, D.*; Escalante, J.; Jiao, X.-Y. Solvent Effects in the β-(Phosphatoxy) Alkyl Radical Migration Asrevealed by Deuterium Labelling and 1H NMR Spectroscopy. J. Chem. Soc., Perkin Trans. 2 1997, No. 3, 627–630. DOI: 10.1039/A603916B


1995

5. Escalante, J.; Juaristi, E.* Enantioselective Synthesis of β-Amino Acids. 6. High 1, 2-Stereoinduction in the Preparation of Enantiopure 2 (R)-Hydroxy-3 (R)-N-Benzoylamino-3-Phenylpropionic Acid (like Stereoisomer of Taxol’s Side Chain). Tetrahedron Lett. 1995, 36 (25), 4397–4400. DOI: 10.1016/0040-4039(95)00859-B


1993

4. Juaristi, E.*; Escalante, J. Enantioselective Synthesis Of. Beta.-Amino Acids. 4. 1, 2 Asymmetric Induction in the Alkylation of 1-Benzoyl-3, 6 (S)-Dimethylperhydropyrimidin-4-One. Preparation of the like and Unlike Stereoisomers of 2-Methyl-and 2-Benzyl-3 (S)-Aminobutanoic Acid. J. Org. Chem. 1993, 58 (8), 2282–2285. DOI: 10.1021/jo00060a051


1992

3. Juaristi, E.*; Escalante, J.; Lamatsch, B.; Seebach, D. Enantioselective Synthesis Of. Beta.-Amino Acids. 2. Preparation of the like Stereoisomers of 2-Methyl-and 2-Benzyl-3-Aminobutanoic Acid. J. Org. Chem. 1992, 57 (8), 2396–2398. DOI: 10.1021/jo00034a037


2. Seebach, D.; Amatsch, B.; Amstutz, R.; Beck, A. K.; Doler, M.; Egli, M.; Fitzi, R.; Gautschi, M.; Herradön, B.; Hidber, P. C. Structure and Reactivity of Five‐and Six‐Ring N, N‐, N, O‐, and O, O‐acetals: A Lesson in Allylic 1, 3‐strain (A1, 3 Strain). Helv. Chim. Acta 1992, 75 (3), 913–934. DOI: 10.1002/hlca.19920750326


1991

1. Juaristi, E.*; Rizo, B.; Natal, V.; Escalante, J.; Regla, I. Alternative Method for the Resolution of 1-Benzoyl-2-Tert-Butyl-3-Methyl-1, 3-Imidazolidin-4-One. Tetrahedron: Asymmetry 1991, 2 (8), 821–826. DOI: 10.1016/S0957-4166(00)80465-6

  • Síntesis de oxaziridinas aquirales y su utilidad en las reacciones de oxidación de carbaniones 
  • Preparación de complejos de cobre con beta-aminoácidos como ligandos
  • Síntesis de beta-pépticos y su posible actividad anticorrosiva y antimicrobiana 
  • Resolución enzimática de gama-amino ácidos
  •  Reducción de Birch e hidrogenación catalítica en quinazolinonas
  •  Síntesis y Resolución de β- y γ-Amino Ácidos Síntesis racémica de beta-2-Aril amino ácidos y beta-2-Aril amino ésteres análogos de la Triptamina 
  • Diseño, preparación, caracterización y evaluación citotóxica de Quelatos de cobre(II) con ligantes β-amino acidatos (Casiopeínas® de tercera generación)

  1. Rodríguez Reyes Mitzi
  2. Leticia Chavelas Hernández
  3. Sánchez Muñoz Grecia Katherine
  4. Jonathan Román Valdez Camacho
  5. Peña Ortiz Daniel
  6. Santos Flores Javier
  7. Alexa Berenice Arroyo Colin
  8. Saúl Osio Becerro
  9. José Daniel Bahena Martínez
  10. Marco Antonio Alcaráz Cano
  11. Anzurez Valdez Giancarlo Bladimir 
  12. Almazán Sánchez Ximena Yatziri 
  13. Guzmán Reyes Fernando Emiliano
  14. Romano Adame Erika Itzel
  15. Santos Flores Javier
  16. Luis Gabriel Hernández Vázquez
  17. Fernando Emiliano Guzmán Reyes
  18. José Enrique Figueroa Portilla 
  19. Víctor Patricio Hernández
  20. Rubén David González Celis
  21. Sebastian Villanueva Aguilar
  22. Mitzi Rodríguez Reyes
  23. Sebastián Villanueva Aguilar
  24. Mirza Nahomi Rodríguez Ginez
  25. Pedro Ángel Cid Jiménez


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